This dissertation aims to: 1) characterize the range of beliefs museum practitioners have about racial, ethnic, and cultural diversity; 2) their understanding of the role of race, culture, and ethnicity in minoritized learners’ sensemaking; and 3) the areas of tension and symmetry between practitioners’ values and their perception of their...
Herpes simplex virus (HSV) is a ubiquitous human pathogen capable of causing debilitating diseases such as herpes stromal keratitis (HSK) and herpes simplex encephalitis (HSE). Although HSV infection initiates disease pathogenesis, the resulting clinical manifestations are attributed to immunopathological events that occur following viral clearance. To elucidate the molecular mechanisms...
Natural Killer (NK) cell dysfunction is associated with poorer clinical outcome in cancer patients. What regulates NK cell dysfunction in tumor microenvironment is not well understood. NKG2D/NKG2DL pathway is very well recognized as an effective immune axis in tumor immunosurveillance. Abundant evidence from experimental preclinical animal models as well as...
Cytokines made by macrophages play a critical role in determining the course of Legionella pneumophila infection. Prior, murine-based modeling indicated that the cytokine response initiated upon recognition of L. pneumophila involves a subset of Toll-like receptors, namely TLR2, TLR5, and TLR9. Using shRNA/siRNA knockdowns and subsequently CRISPR/Cas9 knockouts (KO), I...
Humans have a remarkable ability to create stable walking patterns that can resist and recover from perturbations. Unfortunately, this ability is substantially impaired after a stroke, limiting mobility and contributing to a high fall rate. To facilitate gait training during post-stroke rehabilitation, clinicians often incorporate body-weight support (BWS) systems that...
Superconducting circuits are electrical circuits fabricated from superconducting materials. Due to the engineered strong interactions and suppressed sensitivity to environmental noise, such systems hold substantial promise as quantum bits, in which quantum information can be stored and manipulated with high fidelity. Over the decades, great efforts have been devoted to...
In nearly all Eukaryotes, the membrane-enclosed nucleus contains the vast majority of the cellular genome. Within this sub-cellular compartment, the nuclear architecture facilitates genomic chromatin organization. Controlling chromosomal loci’s spatial positioning relative to subnuclear structures and each other can have local and global effects on gene expression. Moreover, chromatin organization...
Competitive gaming, or esports, is a high-skill endeavor embedded in a highly gendered social context. Using multiple methodological approaches, this dissertation argues that gender-gaming inequality is a result of changeable stereotypes that impact women throughout their lives. Specifically, gender-gaming stereotypes limit women’s initial access to gaming, discourage their continued interest...
We structure our lives around social groups – belonging to them and thinking about them. In this dissertation, I develop a new stereotype content measure to assess the attributes associated with groups in America today, propose and support a theory of sociocultural essentialism, and explore the strategic activation of sociocultural...
This dissertation argues that the nineteenth-century construction of “emotional susceptibility” turned a much-derided quirk of psychology—the long retention of one’s earliest affective impressions—into a basis for radical interventions into thinking about attachment, ethics, and the Victorian novel. I focus in particular on the work of Henry Mackenzie, Charlotte Brontë, George...