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Filtering by: Creator Stojkovska, Iva Keyword induced pluripotent stem cell models Keyword protein aggregation Subject Molecular biology Subject Neurosciences

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1. The Role of Alpha-Synuclein Aggregation in Endoplasmic Reticulum Protein Folding and Homeostasis

Description:: Protein homeostasis, or proteostasis, is essential for preserving all cellular functions and involves a balance of protein synthesis, folding, trafficking, and degradation. A collapse in proteostasis is a common feature of many neurodegenerative disorders that are characterized by the accumulation of insoluble protein aggregates in the brain. Parkinson’s disease (PD)...
Keyword:: induced pluripotent stem cell models, ER stress, protein aggregation, protein folding, and lysosomal dysfunction
Subject:: Molecular biology and Neurosciences
Creator:: Stojkovska, Iva
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/02/2022
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_850723 and http://dissertations.umi.com/northwestern:15793

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1. The Role of Alpha-Synuclein Aggregation in Endoplasmic Reticulum Protein Folding and Homeostasis