Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Glioblastoma (GBM) is the most common aggressive primary malignant brain tumorin adults with a median age of onset of 65 years of age. Although advanced age is often associated with worse GBM patient survival, the predominant source(s) of maladaptive aging effects remains to be established. Here we studied intra-tumoral and...
Keyword:: Senescence, p16INK4a, Glioblastoma, Aging, and Immunotherapy
Subject:: Biology and Neurosciences
Creator:: Bell, April Charlotte
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 08/23/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16795 and etdadmin_upload_1016132

Description:: Stimulation of the cGAS-STING (cycle GMP-AMP synthase-Stimulator of Interferon Genes) pathway increases T cell activation and tracking into the tumor and reverses the immunosuppressive phenotype of myeloid cells. Direct targeting of the STING receptor using synthetic cyclic dinucleotide (CDN) ligands represents an attractive immunotherapeutic strategy for the treatment of lymphocyte-depleted...
Keyword:: GBM, Spherical nucleic acids, cGAS, Immunotherapy, and STING
Subject:: Biology, Biochemistry, and Immunology
Creator:: Mahajan, Akanksha Sanjay
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 05/31/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_983546 and http://dissertations.umi.com/northwestern:16516

Description:: Cell-based therapies are an exciting frontier in medicine. This field is built on a simple premise—cells can be engineered to recognize and treat various human diseases. The paradigm of cell-based therapy uses biosensors to interrogate a cell’s environment and distinguish disease from health, intracellular signaling pathways and genetic circuitry to...
Keyword:: Cell-based therapy, Synthetic receptors, Synthetic biology, Biosensors, Transcription factors, and Immunotherapy
Subject:: Bioengineering, Biology, and Medicine
Creator:: Donahue, Patrick Sean
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Modified:: 05/06/2022
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15420 and etdadmin_upload_781062

LIBRARIES | ARCH