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- Description:
- Nucleic acids not only are the building blocks of life but also a class of attractive macromolecular therapeutics. However, the delivery of therapeutic oligonucleotides into cells has been a major challenge due to their large size and highly negatively charged backbone. Spherical nucleic acids (SNAs) are a class of emerging...
- Keyword:
- Nanomedicine, Gene regulation, and Drug delivery
- Subject:
- Materials Science, Biomedical engineering, and Chemical engineering
- Creator:
- Zhu, Shengshuang
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_672179 and http://dissertations.umi.com/northwestern:14728
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- Description:
- When a cell divides, it must assemble a microtubule-based structure called a spindle, which provides the forces that physically segregate the chromosomes. In most cell types the microtubules that comprise the spindle are nucleated and organized by centriole-containing centrosomes. In many species, however, oocyte meiosis is carried out in the...
- Keyword:
- Kinesin, Cell Division, Spindle, Meiosis, and Microtubule
- Subject:
- Biology
- Creator:
- Mullen, Timothy James
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_640242 and http://dissertations.umi.com/northwestern:14538
-
- Description:
- Automated sketch collaborators might help us create more dynamic intelligent tutoring systems, work out designs, reduce bias in solving spatial social problems, and organize our ideas. Here, we examine some properties of sketch recognition methods designed to help serve that goal. Structure Mapping techniques are applied to symbolic structural descriptions...
- Keyword:
- Near-misses, Case-based reasoning, Structure Mapping, Sketch recognition, Analogy, and Support Vector Machines
- Subject:
- Artificial intelligence and Computer science
- Creator:
- McLure, Matthew David
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14531 and etdadmin_upload_640032
-
- Description:
- We use Goerss-Hopkins theory to show that if E is a p-local Landweber exact homology theory of height n and p > n^2 + n + 1, then there exists an equivalence hSpE ≃ hD(E∗E) between homotopy categories of E-local spectra and differential E∗E-comodules, generalizing Bousfield’s and Franke’s results to...
- Keyword:
- Chromatic homotopy theory
- Subject:
- Mathematics
- Creator:
- Pstragowski, Piotr Tadeusz
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14702 and etdadmin_upload_667235
-
- Description:
- Unlike other products or services, electricity cannot be easily stored, and its delivery cannot be delayed by keeping customers in queues. The electricity supply has to be instantly available to serve a continuously varying demand. Traditionally, electric utilities would match their supply to the demand by adjusting the production output...
- Keyword:
- electricity supply chain, demand response, and operations management
- Subject:
- Management, Environmental economics, and Energy
- Creator:
- DURAN, ASLIGUL SERASU
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_627543 and http://dissertations.umi.com/northwestern:14477
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- Description:
- In the Nicomachean Ethics and Politics, I find that Aristotle endorses two distinct forms of political activity. The first form, which I term statesman activity, is intrinsically valuable. Aristotle thinks that we should value this kind of political activity because it is constitutive of human well-being. The second form, which...
- Keyword:
- experience, education, political activity, Aristotle, and ethics
- Subject:
- Philosophy, Classical literature, and Political science
- Creator:
- Cumella, Giuseppe Angelo
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14472 and etdadmin_upload_627287
-
- Description:
- The apolipoprotein E (APOE) E4 isoform is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). While APOE is predominantly expressed by astrocytes in the central nervous system, neuronal expression of APOE is of increasing interest in age-related cognitive impairment, neurological injury, and neurodegeneration. Here we show that endogenous...
- Keyword:
- APOE, Alzheimer, Stem Cells, and CRISPR
- Subject:
- Molecular biology, Medicine, and Neurosciences
- Creator:
- Wadhwani, Anil R
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14520 and etdadmin_upload_639542
-
- Description:
- Natural Language Processing methods have become increasingly important for a variety of high- and low-level tasks including speech recognition, question answering, and automatic language translation. The state of the art performance of these methods is continuously advancing, but reliance on labeled training data sets often creates an artificial upper bound...
- Keyword:
- Word Embeddings, Natural Language Processing, Polysemy, and Neural Networks
- Subject:
- Artificial intelligence and Computer science
- Creator:
- Lucas, Michael Ryan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2017-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_677765 and http://dissertations.umi.com/northwestern:14760
-
- Description:
- Optical coherence tomography (OCT) is a high-resolution, non-contact, three-dimensional imaging technique, which has revolutionized the diagnosis and treatment of retinal diseases. Visible-light OCT (vis-OCT) extends OCT by enabling retinal oximetry – the measurement of oxygen saturation of hemoglobin from within individual retinal blood vessels. Three advances in the vis-OCT technique...
- Keyword:
- ophthalmology, imaging, blood flow, retina, oxygen saturation, and optical coherence tomography
- Subject:
- Physiology, Ophthalmology, and Optics
- Creator:
- Soetikno, Brian
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_625515 and http://dissertations.umi.com/northwestern:14438
-
- Description:
- The blueprint of life is contained within the sequence of an organism’s genome. While virtually all cells of an individual multicellular eukaryotic organism contain a near identical code of nucleic acid sequences, an organism must give rise to and maintain a varied set of cells and phenotypes. As such, sequence...
- Keyword:
- Genome, Epidermal Differentiation, Nuclear Organization, and Transcription
- Subject:
- Molecular biology, Genetics, and Cellular biology
- Creator:
- Garza-Gongora, Arturo
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_617313 and http://dissertations.umi.com/northwestern:14401