Superconducting qubits are among the leading competitors in the race towards building the first full-fledged quantum computer. Using this platform, researchers have for the first time demonstrated computational capability that is beyond the reach of the current classical machines. (This achievement is nicknamed "Quantum Supremacy".) Up to date, however, the...
The nature of dark matter (DM) remains one of the largest open questions in modern physics despite the many searches for particle dark matter around the world. The search for dark matter particles with masses above 5 GeV/$c^2$ is led by the dual-phase xenon time-projection chamber (LXe-TPC) detector technology which...
My research goal is to develop first principles frameworks to interrogate multiphase, multiscale systems. One of my main focus areas is to consistently deconstruct highly nonequilibrium problems into their fundamental components. By using analytical, computational and experimental tools to grasp the key levers controlling such phenomenon, I aim to build...
A major distinction among different skeletal muscles in the human body is the number, size, and arrangement of its cells, referred to as a muscle’s architecture. Muscle architecture is indicative of a muscle’s ability to contract and produce force and, like muscle function, is plastic. While neuromuscular plasticity is the...
This dissertation asks how can researchers more equitably design sociotechnical interventions to support the information work of sheltered emerging adults. Through two research studies, I explore the technology use in fulfilling the information needs among this population as well as how their environment impacts their strengths and information practices. I...
In an era of personalized medicine, the clinical community has become increasingly focused on understanding diseases at the cellular and molecular level. Magnetic resonance imaging (MRI) is a powerful imaging modality for acquiring anatomical and functional information. However, it has limited applications in field of molecular imaging due to low...
Movement is achieved by combining synaptic inputs from various sources and activating motor unit populations. Motor units are the quantal elements of motor control which act as a neuromechanical transducer that converts sensory inputs into motor output. Because of the tight neuromuscular junctions between motoneuron axon terminals and a large...
This dissertation addresses inter alia the problem of certain intertextual discontinuities across Thomas Hobbes’s oeuvre regarding the issue of ecclesiology. I find that these disparities did not result from a change in Hobbes’s private opinions, but from the regicide of 1649 as an event that liberated Hobbes to unveil his...
The BV Laplacian Δ, first introduced by Batalin and Vilkovisky, is a second-order differential operator that appears in the quantum master equation for quantizing gauge theories. The geometric framework for the BV formalism was later recognized by Schwarz as the setting of odd symplectic geometry and Khudaverdian showed that Δ...
Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between both organelles, but their role in normal and diseased human neurons remains unknown. We used super-resolution and live-cell microscopy in human iPSC-derived neurons to demonstrate that mitochondria-lysosome contacts can dynamically form in the soma, axons, and dendrites of human neurons,...