Fat represents an important source of energy for ovarian cancer (OC) cells and is supplied either through import from the tumor milieu or via de novo lipogenesis. During fast tumor growth, when nutrients are scarce, lipogenesis becomes the primary source of fatty acids. Stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in...
From the early usage of metallic thin films as mirrors tracing back to 2900 BC, to the modern thin film photonic circuits as a mature optical processing platform, and to the growing class of atomically-thin two-dimensional (2D) materials with diverse and tailorable properties, thin film materials have played an important...
Since the dawn of mankind, humans have used materials and tools to dominate the world. As our understanding of the fields physics, chemistry and engineering is growing, we are able to artificially create advanced materials with engineered responses. Next step would be to create ‘ smart’ or intelligent materials capable...
Public-facing data-driven technologies such as social media platforms and search engines rely on data producers, such as users and crowd workers, to be feasible and financially sustainable. Recently, it became clear that the goals of these data-driven technologies do not always align with those of the public, causing public backlashes...
Deterministic models are used to explain and predict the dynamics of ecosystems featuring cyclic competition schemes. The models are systems of reaction-diffusion partialdifferential equations that account for species mobility via Fickian diffusion and interspecies interactions according to the competition scheme. Length and temporal scales are
chosen to be appropriate for...
From colonial practices designed to civilize indigenous communities, to counter-terrorism initiatives aimed at de-radicalizing dissidents in the wake of the War on Terror, to controversies over blasphemy and religious harm cases in international law, religious passions have been cast as a specter of unreason, treason, and radicalization. These assumptions sustain...
Cellular translation is responsible for the synthesis of proteins, a highly diverse class of macromolecules that form the basis of biological function. In Escherichia coli, harnessing and engineering of the biomolecular components of translation, such as ribosomes, transfer RNAs (tRNAs) and aminoacyl-tRNA synthetases, has led to both biotechnology products (i.e.,...
Synthesis and characterization of mixed valent molecules which contain two or more metals in different oxidation states is a rich field of chemistry informing fundamental electronic structure and electron transfer theories. Traditionally these studies are concerned with the direct electronic interaction between metals, but recent work on redox non-innocent ligands...
Visual understanding is an important area in artificial intelligence. Many researchers have proposed novel deep learning models for this, which have achieved impressive results. However, deep learning models of visual understanding do not model human-like cognition and are still far from human-level ability. Standard deep learning models do not model...
In this dissertation, I summarize my findings of the dynamics of colloidal suspensions over a large range of volume fractions in two systems: drop impact and film rupture. The existence of a deformable surface in both these systems allows me to capture the consequences of non-Newtonian flow using high-speed imaging....