The Wnt signalling pathway is used multiple times throughout the development of an organism. Early in embryonic development this path is known to be involved in the induction of the ectodermally derived neural crest. The Wnt pathway is also thought to function in other ectodermal cell types. How the same...
A Socratic ASK System: Helping educators provide a Web-based Socratic mentor for learners. An important role an educator can play in a learning environment is making learners aware of issues, nuances, and problems through Socratic questioning. Prior research has shown the potential of Socratic dialogue for increasing reflection and learning....
Regulation of cell cycle and cell death are critical for normal cellular proliferation, tissue homeostasis, animal development, and the pathogenesis of human diseases such as cancer. Irregularities in cell cycle and cell death may result in tumorigenesis. In this dissertation, I describe my studies of a novel gene C53, which...
Counteranion effects on the rate and stereochemistry of propylene polymerization mediated by ion-pair complexes derived from dimethylzirconocene precatalysts activated with strongly Lewis-acidic perfluoroarylmetalloid cocatalyst/activators are shown to arise from the strength of the cation-anion interaction. This is quantified using CS-symmetric Me2C(Cp)(Flu)ZrMe2 (Cp = C5H4, η5 cyclopentadienyl; Flu = C13H8, η5...
This study examines contemporary theatrical, filmic, and pictorial representations of Heinrich von Kleist's 1807 novella, "The Marquise of O--." It particularly focuses on the development of a solo music theatre production by a team of German/American, independent theatre artists, of which I was one, in the auditorium of the German...
Arsenic trioxide exhibits potent antitumor effects in vitro and in vivo, and is widely used in the treatment of acute promyelocytic leukemia (APL) in humans. In addition to APL, arsenic is of potential therapeutic value for the treatment of other hematologic malignancies, including chronic myelogenous leukemia (CML). There is evidence...