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Filtering by: Creator Kim, Soojin Keyword Interorganelle contacts Resource type Dissertation Subject Molecular biology

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1. Misregulation of Mitochondria-Lysosome Contact Sites in GBA-linked Parkinson’s Disease

Description:: Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between both organelles, but their role in normal and diseased human neurons remains unknown. We used super-resolution and live-cell microscopy in human iPSC-derived neurons to demonstrate that mitochondria-lysosome contacts can dynamically form in the soma, axons, and dendrites of human neurons,...
Keyword:: iPSC, Interorganelle contacts, GBA, Lysosome, Mitochondria, and Parkinson's disease
Subject:: Molecular biology, Cellular biology, and Neurosciences
Creator:: Kim, Soojin
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_825288 and http://dissertations.umi.com/northwestern:15606