This dissertation covers the synthesis and study of peptide nucleic acids (PNAs), specifically, derivatives of PNA containing amine-bearing sidechains or cyclopentane portions. PNAs are non-natural nucleic acids that have far reaching potential in therapeutics and nucleic acid detection. Despite immense potential and widespread application, improving on the design and applications...
In this dissertation I examine the relationship between voter turnout and legislative representation in the United States Congress. My main contention is that political elites react to electoral participation in formulating public policies. I posit that the institutional advantages of incumbency in the House of Representative reduces turnout in congressional...
Megakaryocytic cells (Mks) are derived from hematopoietic stem cells (HSCs) and give rise to platelets. Ex vivo culture of HSCs under conditions that promote Mk differentiation has been proposed as a method for producing Mks and platelets for cell therapies. Mk maturation involves the development of polyploid cells via endomitosis,...
Little is known about the transcriptional events underlying megakaryocytic (Mk) differentiation from hematopoietic stem cells. We sought to identify genes and pathways not previously associated with megakaryopoiesis and to evaluate the CHRF-288-11 (CHRF) megakaryoblastic cell line as a model system for investigating megakaryopoiesis.
Using DNA microarrays, Q-RT-PCR, and protein-level assays,...
Undergraduate research on Liberia. Presentation followed by remarks and discussion. This video can be downloaded, but we refer you to the YouTube version for online streaming: https://youtu.be/OWNCehsxBeA
In this work, the processing of the superconductor MgB<sub>2</sub> was studied to create a fundamental scientific background for the production of superconducting composite wires. The synthesis of MgB<sub>2</sub> from Mg and B powders was investigated in situ to determine reaction rates and kinetic parameters for the application of powder-in-tube technology...
My study examines three participatory learning environments in which computer-based tools and improvisational training techniques comprise innovative approaches to teaching performance studies to undergraduate students. For my analysis, I have selected to focus on two classes and one production project. I contend that performance, an interdisciplinary and collaborative art form,...
There is a need for cyclic robots that interact with lower limbs. Such robots will bring new programmability to exercise, rehabilitation, psychophysiology, and physiology, allowing for complete customization of the foot pedal path and dynamics. These robots are novel to the robotics research ¯eld as well, since conventional robotic designs...
Graphene sheets (one-atom-thick, two-dimensional layers of sp2-bonded carbon) are predicted to have a range of unusual properties. Recent studies have shown that individual graphene sheets have extraordinary electrical properties, but an efficient method of graphite exfoliation remains a challenge. A number of approaches to exfoliation have been tried, such as...
Early growth response genes (Egr1-4) are induced as immediate early genes by a variety of extracellular stimuli that influence cellular growth and differentiation. Egr transcriptional regulators modulate gene expression by binding to Egr response elements (ERE) in target genes. In this study, the low affinity p75 neurotrophin receptor (p75NTR) was...