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The Mechanism of Activation and Sensitivity-Tuning of the Calcium-Sensing Receptor

Description:

Transfer of information across membranes is fundamental to the function of all organisms and is primarily initiated by transmembrane receptors. This is an allosteric process and involves conformational coupling between ligand-binding domain and signaling domain of a receptor. This allosteric mechanism of activation is unclear for many receptors. Moreover, for...

Keyword:

GPCR, CaSR, and smFRET

Subject:

Bioinformatics, Biochemistry, and Biophysics

Creator:

Schamber, Michael Robert

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

09/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16268 and etdadmin_upload_929368
Computational Approaches for Enhanced Metabolomics Annotation and DNA-based Biorecording and Data Storage

Description:

Breakthroughs in large-scale biological data collection have resulted in a wealth of -omics (genomics, metabolomics, etc.) datasets in the literature. However, the development of appropriate computational techniques for their analysis is lacking, yet crucial for fully extracting the rich information contained in these datasets. The work in this dissertation describes...

Keyword:

Biorecording, Data Storage, Cheminformatics, Metabolomics Annotation, Machine Learning, and TdT

Subject:

Bioengineering, Bioinformatics, and Biochemistry

Creator:

Strutz, Jonathan

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

09/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_911481 and http://dissertations.umi.com/northwestern:16126

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The Mechanism of Activation and Sensitivity-Tuning of the Calcium-Sensing Receptor

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