Northwestern University

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Investigation of the Initiation, Progression and Treatment of Pediatric Gliomas

Description:

Pediatric high-grade gliomas (pHGGs) are aggressive pediatric CNS tumors and an important subset are characterized by mutations in H3F3A, the gene that encodes Histone H3.3 (H3.3). Substitution of Glycine at position 34 of H3.3 with either Arginine or Valine (H3.3G34R/V), was recently described and characterized in a large cohort...

Keyword:

genetics, G34R, cancer, ATRX, glioma, and AVB500

Subject:

Molecular biology, Biology, and Biochemistry

Creator:

Abdallah, Aalaa Sanad

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

05/31/2023

Date Created:

2023-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16475 and etdadmin_upload_978815