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Genomic Coordination of Hepatic Lipid Metabolism and Fasting by BCL6

Description:

Transcription is tightly regulated to ensure genes are appropriately expressed both temporally and spatially. This tight regulation governs various processes within the cell, such as differentiation and cell identity, cellular maintenance, and dynamic responses to external signals. Transcription factors (TFs) coordinate these various gene programs and in particular, are key...

Keyword:

Repressor, NAFLD, PPAR alpha, BCL6, Transcription, and Metabolism

Subject:

Molecular biology and Biology

Creator:

Sommars, Meredith Anne

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_663025 and http://dissertations.umi.com/northwestern:14672
Loss of Transcriptional Repression by Adipocyte BCL6 Results in Adiposity and Insulin Sensitivity

Description:

The epidemic of obesity and associated metabolic diseases have led to increased scrutiny of adipose tissue and its primary cell type, the adipocyte. However, studies show that regional adipose tissue distribution rather than obesity per se is a major determinant of metabolic disease risk. Despite having an obese body mass...

Keyword:

Lipogenesis, Insulin Sensitivity, Hypertrophy, Obesity, BCL6, and Adipocyte

Subject:

Biology, Endocrinology, and Genetics

Creator:

Senagolage, Madhavi Dushyanthi

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14575 and etdadmin_upload_658480

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Genomic Coordination of Hepatic Lipid Metabolism and Fasting by BCL6

Loss of Transcriptional Repression by Adipocyte BCL6 Results in Adiposity and Insulin Sensitivity

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