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Investigation of the Initiation, Progression and Treatment of Pediatric Gliomas

Description:

Pediatric high-grade gliomas (pHGGs) are aggressive pediatric CNS tumors and an important subset are characterized by mutations in H3F3A, the gene that encodes Histone H3.3 (H3.3). Substitution of Glycine at position 34 of H3.3 with either Arginine or Valine (H3.3G34R/V), was recently described and characterized in a large cohort...

Keyword:

genetics, G34R, cancer, ATRX, glioma, and AVB500

Subject:

Molecular biology, Biology, and Biochemistry

Creator:

Abdallah, Aalaa Sanad

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

05/31/2023

Date Created:

2023-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16475 and etdadmin_upload_978815
Uncovering modifiers of cardiomyopathy in the noncoding genome

Description:

Heart failure due to genetic cardiomyopathy is associated with a range of phenotypic expression. The studies in this body of work interrogated the role of noncoding variation in modifying cardiomyopathy phenotypes. We used cap analysis of gene expression in heathy and failed left ventricles to define the regulatory environment of...

Keyword:

noncoding, genetics, MYH7, heart failure, modifier, and enhancer

Subject:

Molecular biology, Genetics, and Biochemistry

Creator:

Gacita, Anthony Martin

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_756135 and http://dissertations.umi.com/northwestern:15193

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Investigation of the Initiation, Progression and Treatment of Pediatric Gliomas

Uncovering modifiers of cardiomyopathy in the noncoding genome

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