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- Description:
- Type I interferon (IFN) is the primary antiviral cytokine establishing a broad and potent antiviral response to protect mammalian cells from virus infection. The functional repertoire of IFN extends to innate and adaptive immunity, neoplastic transformation, resistance and cancer immunotherapy. IFN functions are primarily mediated through the Janus kinase (JAK)...
- Keyword:
- ISGF3, Interferon, Chromatin, Antiviral, ISG, and H2A.Z
- Subject:
- Virology, Molecular biology, and Cellular biology
- Creator:
- Au Yeung, Weng Si (Nancy)
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_618020 and http://dissertations.umi.com/northwestern:14409
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- Description:
- This dissertation contains three empirical studies in economic history and labor economics. The first chapter discusses two sources of historical data on work stoppages in the United States: the Third Annual Report of the Commissioner of Labor (1888) and the Tenth Annual Report of the Commissioner of Labor (1896). It...
- Subject:
- Economic history and Economics
- Creator:
- Bittarello, Luca
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14721 and etdadmin_upload_669611
-
- Description:
- The vast majority of interactions between customers and service providers are experiences that extend over time. Service systems that deliver excellent customer experience achieve greater customer satisfaction and therefore customer loyalty, and eventually raise revenue. The temporal aspects of service delivery have not yet been analyzed as carefully as its...
- Keyword:
- Predictive Analytics, Service Operations, Satisfaction, Wait-time, and Markov Decision Process
- Subject:
- Industrial engineering and Operations research
- Creator:
- Ansari, Sina
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_617413 and http://dissertations.umi.com/northwestern:14402
-
- Description:
- Nanocarriers are nanometer-sized (1-1000 nm) structures capable of encapsulating cargo. This encapsulation can drastically alter the pharmacokinetic properties of the cargo, while also allowing for the rational design and engineering of the nanocarrier itself. Poly(ethylene glycol)-block-poly(propylene sulfide) is an amphiphilic diblock copolymer capable of self-assembling into diverse nanocarriers. The purpose...
- Keyword:
- flash nanoprecipitation, nanoparticle, copolymer, anti-inflammatory, and PEG-b-PPS
- Subject:
- Biomedical engineering and Biology
- Creator:
- Allen, Sean David
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14509 and etdadmin_upload_638353
-
- Description:
- Nanomaterials are broadly defined as materials that exhibit at least one dimension that is less than 1,000 nm. Encompassed within nanomaterials are a class of constructs known as nanocarriers, which are applied as delivery vehicles for both encapsulated and covalently bound payloads. Poly(ethylene glycol)-block-poly(propylene sulfide) (PEG-b-PPS) is an amphiphilic block...
- Keyword:
- Sustained Delivery, Surface Functionalization, Nanocarrier, MPS, and PEG-b-PPS
- Subject:
- Biomedical engineering
- Creator:
- Karabin, Nicholas Blaise
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_666953 and http://dissertations.umi.com/northwestern:14700
-
- Description:
- The cellular innate immune response to viruses is a defense mechanism executed by most cells in the human body to form the initial barrier to virus replication. Detection of viral nucleic acids initiates widespread gene expression changes that combine to establish an antiviral state and stimulate professional immune cell activation....
- Subject:
- Molecular biology and Cellular biology
- Creator:
- Kasat, Roli Mandhana
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_618029 and http://dissertations.umi.com/northwestern:14410
-
- Description:
- Functional electronic materials are difficult to design due to the complex interplay among chemistry, atomic structure, and electrical properties. This dilemma is further amplified in transition metal compounds which can defy the band-theory description of non-correlated electrons. Exploring the vast possible design space completely with experiments or first-principles simulations is...
- Keyword:
- Transition metal oxides, Metal-insulator transition, Machine learning, and Data science
- Subject:
- Materials Science
- Creator:
- Wagner, Nicholas Adam
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14800 and etdadmin_upload_685025
-
- Description:
- International media immediately lambasted plans to build a Louvre and a Guggenheim museum in Abu Dhabi, United Arab Emirates (UAE) as the whimsy of wealthy sheikhs using oil money to “buy culture.” The museums are part of a $27b development project called Saadiyat Island. While Saadiyat is spectacular, dismissing it...
- Keyword:
- critique, art, culture, museums, and politics
- Subject:
- Art history, Middle Eastern studies, and Cultural anthropology
- Creator:
- Derderian, Elizabeth
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14736 and etdadmin_upload_674378
-
- Description:
- The purpose of this dissertation is to investigate the adoption of active mobility through the lens of three fundamental concepts: scale, segment, and neighborhood. Scale refers to both the aggregation of geospatial data and the measurement of latent constructs through behavioral survey instruments. Segment refers to the various clustering approaches...
- Keyword:
- active transportation, market segmentation, community, well-being, and travel behavior change
- Subject:
- Geography, Social psychology, and Transportation
- Creator:
- Biehl, Alec Michel
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_685030 and http://dissertations.umi.com/northwestern:14802
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- Description:
- The work in this thesis focuses on computational methods for the identification of novel enzymatic pathways. In particular this work focuses on the utilization of the Biological Network Integrated Computational Explorer (BNICE) software suite to predict de novo enzymatic pathways for the production of commercially relevant compounds and on improvements...
- Subject:
- Bioengineering and Biochemistry
- Creator:
- Stine, Andrew Eugene
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2016-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_614431 and http://dissertations.umi.com/northwestern:14393