The ribosome, the cell’s machine for synthesizing proteins, can be thought of as the chef of the cell. Just as a chef reads a recipe and combines ingredients to create a dish, the ribosome reads cellular instructions and connects building block molecules (amino acids) to construct proteins. Like the final...
Self-assembly is an important process in biological system to build various bioactive structures from small amphiphilic molecules. The structural versatility of amphiphile self- assembly also provides a unique platform for the design of functional soft materials with controllable structural features. However, little is known about the correlation between external stimuli,...
With the rapidly growing global demand in energy nowadays, innovation and technology become critical for a transition to renewable energy, high energy efficiency or low-carbon emission. Thin-film materials are especially favorable in energy management due to the easy integration into devices. The transport properties for heat and electrical conduction are...
The adoption of surfactant replacement therapy (SRT) for the treatment of neonatal respiratory distress syndrome (nRDS) is one of the main contributors to the dramatic decline in infant mortality rates observed in the 1980s. Despite the significant efficacy of animal-derived surfactant preparations, there are still some concerns associated with their...
While self-consolidating concrete (SCC) may no longer be considered a "new concrete", there are still significant challenges to overcome before there is broader acceptance of SCC. One of these challenges concerns the formwork pressure exerted by SCC. A major advantage of SCC is the accelerated casting process due to the...
This dissertation examines growth of platinum nanoparticles from vapor deposition on SrTiO3 using a characterization approach that combines imaging techniques and X-ray methods. The primary suite of characterization probes includes atomic force microscopy (AFM), grazing-incidence small-angle X-ray scattering (GISAXS), X-ray fluorescence (XRF), scanning electron microscopy (SEM), and X-ray absorption spectroscopy...
ZnO is a member of the unique class of materials known as transparent conducting oxides (TCOs). TCOs are currently used for many applications including flat panel displays, solar cells, and energy efficient windows. Of particular interest is the possibility of developing materials that have high electron mobilities, such that conductivities...
Wood-derived ceramics and composites have been of interest in recent years due to their unique microstructures, which lead to tailorable properties. The porosity and pore size distribution of each wood type is different, which yields variations in properties in the resultant materials. The thermal properties of silicon carbide ceramics and...
The research reported in this dissertation covers the development of two high-performance concrete materials, Very-High-Strength Concrete (VHSC) and Frangible Concrete, and the philosophy of engineering the microstructure of these materials to produce their specific beneficial traits. The underlying problem addressed was how to optimize their design to maximize their desirable...
This thesis focuses on resource allocation in wireless communication and networking. Resource allocation has been studied widely, for example, to maximize the system-wide throughput or to minimize the average delay per user. Moreover, the utility-based framework is becoming an important tool for addressing fairness and Quality-of-Service (QoS) for individual users....
Recent assessment of material property requirements for blast resistant applications, especially for the naval ship hulls, has defined the need to design steels with high stretch ductility and fragment penetration resistance, along with high strength and adequate toughness. Using a system based computational materials design approach, two series of austenitic...
A critical challenge in improving the quality of life for spinal cord injury survivors is to restore the capacity to grasp and manipulate objects. While progress has been made to restore hand function by using functional electrical stimulation (FES) to activate muscles, providing the means to control the multiple degrees...
Tissue engineering offers a promising approach for the replacement of diseased or injured tissues, and is based upon the premise that cells can be induced to form new tissues when presented with the appropriate set of environmental cues. Polymer scaffolds play a central role in most tissue engineering strategies by...
A multicomponent bimodal poly(vinyl acetate) (PVAc) polymer composite has been scientifically designed to increase biaxial plastic flow stabilization for the achievement of large biaxial deformations. For this, a systems-based approach was used for the computational materials design of a high performance bubblegum whose mean in-vivo bubble diameter exceeds that of...
As device sizes decrease, more functionality can be placed in an integrated circuit. Therefore, the design complexity of these circuits increases. To deal with complexity, designers move to higher abstraction levels. Currently, the highest abstraction level is the system-level. In our work we investigate the synthesis and verification problem at...
Recent work points out the importance of the solid-solid interface in explaining the high photoactivity of mixed phase TiO2 catalysts. The goal of this research was to probe the synthesis-structure-function relationships of the solid-solid interfaces created by the reactive direct current (DC) magnetron sputtering of titanium dioxide. I hypothesize that...
Increasing interest in long-life bone implants with reduced mechanical properties reducing the stress-shielding effect and a structure mimicking bone porous architecture has encouraged study and development of fabrication methods for porous NiTi. The main objective of this work was to advance these goals by developing new processing procedures for porous...
Motivated by performance requirements of future medical stent applications, experimental research addresses the design of novel TiNi-based, superelastic shape-memory alloys employing nanoscale precipitation strengthening to minimize accommodation slip for cyclic stability and to increase output stress capability for smaller devices. Using a thermodynamic database describing the B2 and L21 phases...
In recent years, research has expanded the uses of triblock copolymer gels to a wide variety of applications including everything from ceramics processing to regenerative medicine and drug delivery. The research presented in this dissertation focuses on a physically crosslinked, block copolymers gel system in a selective solvent. This system...
Atrial fibrillation (AF) is the most common supraventricular tachyarrhythmia and its prevalence is expected to increase with the aging population. However, the mechanisms AF initiation, maintenance and termination are not completely understood. The surface electrocardiogram (ECG) characteristics are a direct reflection of pathophysiologic events in the atria and can be...