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- Description:
- Uterine leiomyoma (LM), the most common tumor of women, causes severe morbidity. LM cells can be separated into three molecularly and functionally distinct cell populations based on the expression pattern of CD34 and CD49b: stem (LSC, CD34+/CD49b+), intermediate (LIC, CD34+/CD49b-), and differentiated cells (LDC, CD34-/CD49b-). Progesterone via progesterone receptor (PR/PGR)...
- Keyword:
- RANK/RANKL pathway, Progesterone signaling, Tumor stem cell, DNA methylation, and Uterine leiomyoma
- Subject:
- Biology
- Creator:
- Liu, Shimeng
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15024 and etdadmin_upload_722143
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- Description:
- This thesis explores questions in labor economics and applied microeconomics, with particular focus on issues that have implications for public policy. The first essay estimates the Frisch elasticity, sometimes known as the wage elasticity of labor supply in response to anticipated wage changes. Despite its importance in macroeconomic and public...
- Keyword:
- Public Economics, Applied Microeconomics, and Labor Economics
- Subject:
- Economics
- Creator:
- Ong, Pinchuan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_737671 and http://dissertations.umi.com/northwestern:15058
-
- Description:
- Over 6 million adults in the United States have heart failure, a serious public health problem. Differences in the progression of heart failure are in part due to variability in sex, age, and genetic variation background including ancestry. Medical biobanks provide a resource to study this variability as they include...
- Subject:
- Bioinformatics and Genetics
- Creator:
- Pottinger, Tess D
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_742461 and http://dissertations.umi.com/northwestern:15091
-
- Description:
- This dissertation presents research on the game theory of political power, both between and within nations. It first revisits a classical distinction between three different types of power or influence: information, rewards and threats. By presenting a binary-action Principal-Agent problem which incorporates the essential ingredients of all three types of...
- Keyword:
- Game Theory, Mechanism Design, and Political Economy
- Subject:
- Economics, Political science, and Economic theory
- Creator:
- Theisen, Alexander Scott
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_742509 and http://dissertations.umi.com/northwestern:15094
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- Description:
- The advent of sequencing technologies has generated a large amount of biological and medical data. These data such as genetic sequencing data and lab experimental evidence data can help understand critical biomedical problems. This dissertation makes contribution in three different but related applications in biomedical research. In Chapter 2, we...
- Keyword:
- Normalization, Metagenomics, Graph neural network, Clustering, and Differential abundance test
- Subject:
- Biostatistics, Statistics, and Bioinformatics
- Creator:
- Ma, Yuanjing
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15057 and etdadmin_upload_736532
-
- Description:
- Natural products from fungi have had an immeasurable societal impact as both friends and foes to human health. This includes numerous therapeutics that have had widespread clinical success, mycotoxins that are implicated in fungal pathogenicity, and various agrochemicals. Recent genome sequencing efforts have revealed that fungal genomes contain the capacity...
- Subject:
- Biochemistry
- Creator:
- Robey, Matthew
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_731063 and http://dissertations.umi.com/northwestern:15039
-
- Description:
- This dissertation explores the interaction of debt covenants and firms’ investment behaviors, especially the association between debt covenants and project-level operations. Although previous research has examined the association between contractual terms or gross measures of investment and covenants, there is little known about the ways that covenants influence the choice...
- Subject:
- Accounting
- Creator:
- Rigsby, Christopher
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15083 and etdadmin_upload_741862
-
- Description:
- Interactions between working memory and long term memory systems are still not well understood, as the systems have long been thought to be mostly separate. An interesting intersection of these memory systems is domain-specific expertise, whereby individuals are able to show supra-span memory for information related to the area of...
- Keyword:
- Domain-specific expertise, Long term memory, Working memory, and Expertise
- Subject:
- Psychology and Neurosciences
- Creator:
- Gigler, Kathryn Lee
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_743356 and http://dissertations.umi.com/northwestern:15112
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- Description:
- Atrial fibrillation (AF) is the most common cardiac arrhythmia, and associated with increased risk for ischemic stroke and mortality. While the risk of stroke has been shown to be reduced with the use of oral anticoagulants like Warfarin, these medications are predictably linked with an increased risk of bleeding, and...
- Keyword:
- Multidimensional imaging, Unicuspid aortic valves, Cardiac MRI, 4D flow MRI, Atrial fibrillation, and Magnetic Resonance Imaging
- Subject:
- Biomedical engineering, Medical imaging, and Engineering
- Creator:
- Ma, Liliana Esther
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_723481 and http://dissertations.umi.com/northwestern:15025
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- Description:
- In machine learning, classification that assigns a label to a sample is a fundamental problem and serves a building block for various applications of artificial intelligence such as speech recognition, sentimental analysis, and image recognition. During the last years, deep learning rejuvenates artificial intelligence; in particular, it leads to tremendous...
- Keyword:
- Classification, Deep learning, and Machine learning
- Subject:
- Industrial engineering
- Creator:
- Koo, Jaehoon
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15036 and etdadmin_upload_729998