Uranium is a unique, multifaceted element that possesses rich chemistry and promise for challenging reactions. Pressing demands within nuclear stockpile stewardship and the nuclear energy sector call for development of this relatively understudied element. Uranium metal–organic frameworks (U-MOFs), a class of nanoscale hybrid materials, harness the exceptional attributes of uranium...
Uranium is a unique, multifaceted element that possesses rich chemistry and promise for challenging reactions. Pressing demands within nuclear stockpile stewardship and the nuclear energy sector call for development of this relatively understudied element. Uranium metal–organic frameworks (U-MOFs), a class of nanoscale hybrid materials, harness the exceptional attributes of uranium...
DNA is extremely versatile and powerful, both as a construct in biological applications and as a ligand in materials design due to the fact that its recognition properties can be programmed through sequence and length. Spherical nucleic acids (SNAs), nanoparticles surrounded by a dense shell of DNA or RNA, are...
Mixed-dimensional heterojunctions between two-dimensional (2D) materials and organic semiconductors is a rapidly growing field. This is motivated by the promise of leveraging the extraordinary properties of 2D materials with the synthetic tunability and reconfigurability of organic electronics, allowing the realization of new physics or devices that are not possible in...
The objective of molecular imaging is to noninvasively visualize biochemical events in a living system at the cellular level. Magnetic resonance imaging (MRI) is a promising modality for this goal due to its excellent resolution, unlimited depth penetration, and absence of harmful ionizing radiation. MRI techniques frequently use Gd(III)-based contrast...
Many transcription factors (TFs) regulate oncogenic processes and are therefore desirable targets for drug intervention. However, few TF inhibitors have been developed to date due to a lack of specificity and few TF binding pockets. The Meade Lab has overcome these challenges by using cobalt-based complexes that disrupt Cys2His2 zinc...