Promyelocytic leukemia (PML) nuclear bodies act as quality control centers in the nucleus, participating in a plethora of nuclear functions. As such, PML bodies are a signature model for functional nuclear organization. PML bodies have a dynamic protein composition that responds to changing conditions of the cell. Many of the...
Psychosocial stress is part of everyday life, and while ubiquitous, stress plays a huge role disease development and treatment. Though the stressor’s intensity, predictability, and frequency (acute vs chronic) are important determinants of disease development, interactions with one’s genetic and epigenetic make-up also play a causal role. Major Depressive Disorder...
Loneliness, Stress, and Depression over the Transition to Adulthood: Interpersonal and Physiological Pathways Leah Darrah Doane During the transition into adulthood, youth experience substantial stressful changes as they navigate shifts in their interpersonal, familial, educational and economic domains of life. This dissertation aims to understand how the unique experiences of...
Achievement gaps between students from different SES and racial/ethnic backgrounds stubbornly persist despite decades of policy interventions. My dissertation focuses on several unexpected sources of stress and disruption that may be related to the achievement gap: sunlight exposure, a sister’s teen childbearing, and nearby violent crime. I demonstrate that these...