Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Methanotrophs, bacteria that can metabolize methane, remain a promising solution to mitigating the effects of climate change by removing atmospheric methane and converting it to useful chemical precursors. However, a full understanding of the main enzyme they use to oxidize methane, particulate methane monooxygenase (pMMO), is critical for harnessing their...
Keyword:: cryogenic electron tomography, particulate methane monooxygenase, membrane protein, cryogenic electron microscopy, and cell-free protein synthesis
Subject:: Molecular biology, Biochemistry, and Biophysics
Creator:: Koo, Christopher Wellington
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_897671 and http://dissertations.umi.com/northwestern:16003

Description:: DNA double-strand breaks (DSBs) are caused by either endogenous agents or exogenous ionizing radiation and chemicals. Incorrect DSB repair can lead to undesired genome rearrangements. Homologous recombination (HR) and non-homologous end-joining (NHEJ) pathways are two major DNA repair pathways that repair DSBs and maintain genome integrity. When homologous DNA is...
Keyword:: DNA repair, Cryo EM, NHEJ, DNA-PKcs, Cancer, and CRISPR
Subject:: Molecular biology, Biochemistry, and Biophysics
Creator:: Chen, Siyu
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_879511 and http://dissertations.umi.com/northwestern:15936

Description:: The purpose of my thesis research has been to understand the formation of mitotic chromosome structure by using chromosome micromanipulation. Folding mitotic chromosomes from their loose interphase form into their individualized, compacted form is required for easy handling of the chromosomes for cell division. This process is facilitated by several...
Keyword:: Mitosis, Histone PTMs, Chromosomes, SMC Complexes, Biophysics, and Meiosis
Subject:: Molecular biology and Biophysics
Creator:: Biggs, Ronald Joseph
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/02/2022
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15852 and etdadmin_upload_862016

Description:: In nearly all Eukaryotes, the membrane-enclosed nucleus contains the vast majority of the cellular genome. Within this sub-cellular compartment, the nuclear architecture facilitates genomic chromatin organization. Controlling chromosomal loci’s spatial positioning relative to subnuclear structures and each other can have local and global effects on gene expression. Moreover, chromatin organization...
Keyword:: Genome, Yeast, Statistics, Nucleus, Epigenetics, and Diffusion
Subject:: Molecular biology, Genetics, and Biophysics
Creator:: Sumner, Michael Chas
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15670 and etdadmin_upload_837750

Description:: Transcription of nucleic acids (DNA and RNA) is a hallmark of life, taking the information stored within genomic nucleic acids and converting it into a form that is useful for producing the proteins necessary for cellular and organismal function. In eukaryotes, transcription of DNA into messenger RNA (mRNA) requires the...
Keyword:: Virology, Paramyxovirus, Cryo-EM, Mediator, Polymerase, and Transcription
Subject:: Molecular biology, Biochemistry, and Biophysics
Creator:: Abdella, Ryan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 04/15/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15490 and etdadmin_upload_797897

Description:: Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated Cas proteins provide an immune-like response in many prokaryotes against extraneous nucleic acids. CRISPR-Cas systems are classified into different classes and types that vary widely in composition, target recognition, and overall mechanism. The main division of CRISPR-Cas systems occurs between...
Keyword:: Staphylococcus epidermidis, X-ray crystallography, Cryo-EM, Csm3, CRISPR, and Csm2
Subject:: Molecular biology, Biochemistry, and Biophysics
Creator:: Dorsey, Bryan William
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_655609 and http://dissertations.umi.com/northwestern:14567

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