While infrequent, clay slope failures caused by earthquakes result in loss of life and substantial property damage. In strong seismicity areas, it is sometimes assumed that the stability of clay deposits can be evaluated through the residual undrained strength that is applicable at large deformations. A crucial factor missing in...
A disconnect exists between the behavior of transcriptional and genetic regulation in bacterial systems when comparing phenotypic patterns and dynamics of a population to those observed at the single cell level. In this thesis, we developed a number of tools and assays to better understand, overcome, and predict the challenges...
CD1 molecules represent a class of antigen presenting molecules that present lipid antigens to cognate T cells. These molecules have been identified in all mammals examined so far. Unlike MHC molecules, which are highly polymorphic, CD1 molecules exhibit limited polymorphism and are divided in to two groups – 1 and...
Substance use and substance use disorder (SUD) may be variables that influence the course of HIV/AIDS risk behaviors as youth age. To our knowledge, no prospective longitudinal study has examined the association between categories of substance use disorders including alcohol use disorder alone, marijuana use disorder alone, comorbid drug use...
How mental representations are constructed and how they evolve are central problems for cognitive science. Representation decisions help determine what computations are hard or easy. Structured, relational representations are a hallmark of human cognition. Developmental studies show that children do not perform as well as adults in tasks that require...
This project examines the uneven adoption of therapeutic initiatives within the organizational field of American museums to ask: How do people frame museum-going as “good” for visitors’ health? Existing research on legitimation processes would predict cultural institutions respond similarly to pressures for greater accountability from their external environments, or resist...
Consider the role of waiting rooms as informal learning environments. In this thesis, I examine a pediatric hematology and oncology clinic to evaluate the patient learning experience. Through staff interviews, waiting room observations, and a review of educational materials I argue that this process is in need of redirection. Most...
In 2012 the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC) collected 19.7 fb-1of data at a center of mass energy of 8 TeV. This thesis presents two analyses focusing on the Z boson. The first is a search for the never before seen decay of a...
Surface-enhanced Raman spectroscopy (SERS) is a powerful technique for characterizing molecular systems. It combines the chemical selectivity of vibrational spectroscopy with plasmonic signal enhancement to achieve the ultimate limit of detection--a single molecule. By overcoming the effects of ensemble averaging, single molecule SERS (SMSERS) probes distributions in molecular interactions and...
Planets and planetary systems change in brightness as a function of time. These "light curves" can have several features, including transits where a planet blocks some starlight, eclipses where a star obscures a planet's flux, and rotational variations where a planet reflects light differently as it spins. One can measure...