Kinesin-1 is a motor protein that transports cargo along microtubules. Inside cells, the majority of kinesin-1 is regulated to conserve ATP and ensure its proper intracellular distribution and coordination with other motors. Regulated kinesin-1 is folded in half, and interactions between coiled-coil regions near the N-terminal enzymatically active heads and...
A tetramer model for HIV-1 Integrase (IN) with DNA representing the LTR termini was previously assembled which predicted amino acid residues on the enzyme surface that interact with the LTR termini (Chen et al, 2006). A separate structural alignment of HIV-1, SIV, and ASV INs predicted which of these residues...
The recent years have witnessed a large number of emerging applications in location based services, thanks to the wide spread use of GPS devices, cellular phones, RFID tags and mobile sensor nodes. A fundamental technology that enables such services is the efficient management of the vast volume of spatio-temporal information...
The de novo design of bio-inspired materials with precisely controlled properties is challenging, but has potential applications in nano-biotechnology. Applications range from nanometer scaled assemblies to three-dimensional scaffolds for tissue engineering. Genetic engineering of protein-based polymers offers distinct advantages over traditionally synthesized polymers, de novo proteins can be produced with...
This dissertation traces the meaning and scope of early modern complaint poetry. I argue that what I understand as a secular "poetics of dissatisfaction" arose to fill the void left when religious auricular confession was no longer an institutionalized practice, and that this mode of literary expression was itself shaped...
Loneliness, Stress, and Depression over the Transition to Adulthood: Interpersonal and Physiological Pathways Leah Darrah Doane During the transition into adulthood, youth experience substantial stressful changes as they navigate shifts in their interpersonal, familial, educational and economic domains of life. This dissertation aims to understand how the unique experiences of...
The goal of this dissertation is to improve our understanding of the driving forces behind short-term movements in important aggregate variables such as exports, imports, the trade balance, output, investment, and employment. The first chapter contrasts the cyclical behavior of the trade balance and trade flows in a group of...
The growing worldwide threat of antibiotic-resistant pathogens has necessitated a constant search for new classes of antibiotics. Antimicrobial peptides (AMPs) are integral components of innate immunity in virtually every living organism, and, due to their proven efficacy over millions of years of evolution, are considered promising leads for new antibiotic...
Recent work points out the importance of the solid-solid interface in explaining the high photoactivity of mixed phase TiO2 catalysts. The goal of this research was to probe the synthesis-structure-function relationships of the solid-solid interfaces created by the reactive direct current (DC) magnetron sputtering of titanium dioxide. I hypothesize that...
One of the central features of the now half-century old theory of the microscopic origins of superconductivity in elemental materials is the correlations between pairs of electrons with opposite spin and momentum. The constituent electrons of these Cooper pairs have the unusual property that their mean spatial separation is much...