CD95/Fas ligand (CD95L) is a well characterized activator of extrinsic apoptosis. CD95L protein binds to its cognate receptor, CD95/Fas/APO-1, inducing apoptotic signaling in sensitive cells. However, expression of CD95L is toxic even in the absence of CD95. We previously reported that the CD95L open reading frame (ORF) is enriched for...
Involuntary motor activities such as spasms arise from hyperreflexia in about 70% of individuals with spinal cord injuries (SCI). Despite this prevalence and the negative impact on health and safety, it is unclear what determines the severity of the spasms that develop. This study investigated the impact of injury severity...
Uranium is a unique, multifaceted element that possesses rich chemistry and promise for challenging reactions. Pressing demands within nuclear stockpile stewardship and the nuclear energy sector call for development of this relatively understudied element. Uranium metal–organic frameworks (U-MOFs), a class of nanoscale hybrid materials, harness the exceptional attributes of uranium...
In the 1960s, the International Theatre Institute (ITI), the organization sponsored by the United Nations Educational, Scientific and Cultural Organization (UNESCO) with a mission to represents the world’s theaters, was faced with a crisis of representation. After twenty years of existence, the institution had not succeeded in substantially expanding beyond...
Monetary Policy plays a crucial role in modern economies by supporting price, financial and economic stability. Its efficacy, however, exhibits variation both over time and across space leading to partially unpredictable and inconsistent outcomes. This thesis shows that the variation in the efficacy of monetary policy crucially relates to the...
The goal of this thesis is to prove that topological restriction homology, TR, is locally even in the quasi-syntomic topology in characteristic p. This local evenness was already known for the other main trace theories, but is more subtle for TR.
We consider data-driven approaches for universal texture modeling via generative adversarial networks and inversion methods. We investigate the properties of the learned representation spaces and demonstrate that a strong link between texture analysis and synthesis is the key to successful texture modeling. First, we visit the problem of texture synthesis...
Previous studies have documented a systematic discrepancy between probabilistic seismic hazard maps and historical records of shaking (Stein et al., 2015; Brooks et al., 2016, 2017, 2018, 2019; Salditch et al., 2020; Salditch, 2021). In almost every case, shaking predicted by the hazard map is higher than that historically observed....
This dissertation includes the score and companion essay to the musical work, Untitled (March). In the composition, I endeavor to create a listening situation offering a mutually negotiated environment of quietude that challenges a listener's preconceptions of intentionality and perception by blurring the boundaries between instrumental performance, field recordings, and the...
Due to their widespread applicability, graphs and networks appear in various contexts. The increasing scale of graphs encountered in the real-world requires the developmentof efficient algorithms that run reasonably fast and produce close to optimal solutions.
The main focus of this thesis is the development of fast graph algorithms for...