Bacterial infections (BI) are a frequent, expensive, and life-threatening condition for critically ill patients. For patients with serious BI, minimizing the time between admission to the
intensive care unit (ICU) and administration of appropriate antibiotic therapy is crucial to
improve prognosis. However, the current gold-standard for identifying the appropriate
antimicrobials...
Understanding the complex genome-phenome associations behind human complex traits will be a primary focus for the practice of precision medicine in the future. Identifying the genetic variants that contribute to the inter- and intra- phenotypic variations of individuals, elucidating pleiotropic architecture of common complex traits, and demonstrating how personal biomedical...
Annual age-adjusted breast cancer incidence rates in the United States have been static for decades. More recently, the development of massively parallel, high throughput DNA sequencing has enabled the cataloging of somatic mutations in cancer. Mutations are non-random and occur within sequence motifs. These motifs provide us with evidence to...