In financial risk management, coherent risk measures have been proposed as a way to avoid undesirable properties of measures such as value at risk that discourage diversification and do not account for the magnitude of the largest, and therefore most serious, losses. A coherent risk measure equals the maximum expected...
Following dopaminergic denervation in Parkinson's Disease, firing patterns in several basal ganglia neuron populations are pathologically altered. In the globus pallidus (GP), this manifests as a loss of autonomous, rhythmic, high-frequency pacemaking and an appearance of correlated, oscillatory bursting. This oscillatory bursting is best disrupted through high-frequency stimulation of affected...
Reactivation of latent human cytomegalovirus is of significant concern in immunocompromised transplant patients. However, the mechanisms controlling reactivation of latent CMV have not been understood. It is likely that reactivation is initiated by induction of IE gene expression. In this thesis, I studied molecular mechanisms leading to transcriptional activation of...
Effective and reliable material and structure as bone implant have been a continuing challenge for scientists from bioengineering, material science and mechanical engineering. Porous titanium has reduced stiffness comparable to bone and open pores to allow complete bone infiltration, thus making it attractive for bone-replacement implants in biomedical engineering. To...
The Gram-negative bacterium <em> Vibrio cholerae </em> elicits disease through the export of enterotoxins. The <em> V. cholerae </em> RTX toxin was identified due its ability to cause cell rounding. Characterization of the RTX toxin demonstrated that this cell rounding was due to the depolymerization of the actin cytoskeleton through...
Many methods have been proposed for estimating the number, $m_0$ (or the proportion, $\pi_0$), of the true null hypotheses for adaptively controlling a type I error rate (e.g., the false discovery rate or FDR) using a multiple test procedure. Most of these methods eliminate ``significantly" non-null $p$-values. Then $m_0$ is...
This thesis interprets and critiques what is termed the 'myth of oneness' within the western philosophical and theological tradition, seeking to help transform South Korean Christianity, especially its perspective on other religions, and its attitude toward the reunification of Korea. Whitehead's process philosophy and its resulting theology, and the yin-yang...
While the rumors of "worship wars" dividing North American Protestantism are not news, ongoing questions remain concerning the effectiveness of trading in traditional organs for electric guitars and hymnals for PowerPoint. The recent availability of the largest, inter-faith-group, congregational-level data set (n=14,021) and theory development concerning the evolving attractive power...
CD4-positive T cells express ligands for E- and P-selectins, carbohydrate-binding adhesion molecules that are induced on inflamed endothelium. The interaction between selectins and the selectin ligands facilitates the migration of T cells to sites of inflammation. The fucosyltransferase FucT-VII is essential for selectin ligand formation but the signaling and transcriptional...
This dissertation examines the legal, sociological and strategic dimensions of the illegitimate organizational field of cocaine from 1880 to 1930. Volume I includes a comprehensive interdisciplinary examination of the concepts of legitimacy and illegitimacy. Building on existing theories, I also suggest a modest perspective for bringing consumer demand more fully...