Metabolite biosensors are powerful tools for basic biological research, medical diagnostics, and biotechnological applications. However, a generalizable strategy for developing new metabolite biosensors when an existing sensor cannot be found in nature, is a persistent challenge. Furthermore, while transcription factor biosensors have the broadest range of applications, the pool of...
The hormone prolactin (PRL) contributes to breast cancer pathogenesis through various signaling pathways, one of the most notable being the JAK2/signal transducer and activator of transcription 5 (STAT5) pathway. PRL-induced activation of the transcription factor STAT5 results in the upregulation of numerous genes implicated in breast cancer pathogenesis. However, the...
Ultrafast spectroscopy offers an unprecedented view on the dynamic nature of chemical reactions. From charge transfer in semiconductors to folding and isomerization of proteins, these all important processes can now be monitored and in some instances even controlled on real, physical timescales. One of the biggest challenges of ultrafast science...
While literature indicates that fewer than half of older adults aged 65 years or older receive high quality end-of-life care, less is known about the quality of end-of-life care experienced by the segment of that population with multiple chronic conditions (MCC). Drawing upon the Teno Model of high quality end-of-life...
Traditionally, research on perception and sensory systems has considered the senses as independent and modular functions that only converge after sufficient processing in unisensory areas. Recently, however, that view has been called into question with a number of demonstrations of multisensory interactions that may occur as early as primary cortex....
This dissertation investigates the evolution of national identification and assimilative trends among Germans who remained behind in the Czech lands from the end of the postwar expulsions in 1946 through the Czech Republic’s entry to the European Union in 2004. My primary lens of analysis is associational life, or formal...
The goal of this thesis is to design practical algorithms for nonlinear optimization in the case when the objective function is stochastic or nonsmooth. The thesis is divided into three chapters. Chapter 1 describes an active-set method for the minimization of an objective function that is structurally nonsmooth, viz., it...
In Amyotrophic Lateral Sclerosis (ALS), spinal motoneurons degenerate in the order of large motoneurons that innervate fast and fatigable muscle fibers to small motoneurons that innervate slow muscle fibers (Pun et al. 2006). This order of degeneration is peculiar in that it is in direct opposition to the normal order...
Algorithms which are efficient and robust are essential to meet the increasing computational demands in the world today. In this thesis, we consider the analysis and design of both distributed algorithms for dynamic average consensus and centralized algorithms for convex optimization.
Dynamic average consensus consists of a group of agents,...
3D integration of integrated circuits is becoming a prominent solution in the design of high performance chips. Multiple dies can be stacked in a single 3D structure and utilizes Through Silicon Vias (TSV) for die to die communications. While this feature significantly decrease the latency of data transfer, multi-tier stacking...