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- Description:
- Cancer remains a leading cause of death worldwide, necessitating continued study to explore and unravel its complex etiology. For example, there has been a shift of focus in cancer treatment from surgery and radiotherapy to targeted chemo- and immunotherapies as we gain more knowledge on the hallmarks of cancer (e.g.,...
- Keyword:
- tumor microenvironment, nanomedicine, Checkpoint inhibitor, spherical nucleic acids, gene expression/knockdown, and immunotherapy
- Subject:
- Nanotechnology, Oncology, and Immunology
- Creator:
- Chou, Liyushang
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_884998 and http://dissertations.umi.com/northwestern:15965
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- Description:
- Tumor-initiating cells with reprogramming plasticity are thought to be essential for cancer development and metastatic regeneration in many cancers; however, the molecular mechanisms are not fully understood. We have previously identified that CD44, a breast tumor-initiating cell marker, drives mammosphere self-renewal and multicellular aggregation of circulating tumor cell (CTC) clusters,...
- Keyword:
- exosomes, CD44, cancer stem cells, extracellular vesicles, CD81, and breast cancer
- Subject:
- Molecular biology, Biology, and Cellular biology
- Creator:
- Ramos, Erika Kathryn
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16152 and etdadmin_upload_916551
-
- Description:
- Gerotranscendence involves feelings of coherence with one’s sense of self, greater acceptance of one’s own life, and connectedness to others across time and space. Gerotranscendence is thought to increase with age. The present study is the first longitudinal effort to investigate changes in gerotranscendence across late midlife using life story...
- Keyword:
- self-transcendence, gerontology, narrative identity, ego integrity, midlife, and life stories
- Subject:
- Developmental psychology, Personality psychology, and Clinical psychology
- Creator:
- Reischer, Hollen N.
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16318 and etdadmin_upload_938638
-
- Description:
- Given the enormous diversity that exists in our society today, the need intensifies for educators to create a transformative environment that fosters productive encounters with the differences that emerge in a diverse society. Nonetheless, limited attention has been devoted to generating a systematic understanding of how students engage with and...
- Subject:
- Education
- Creator:
- Chang, Amy A
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_947336 and http://dissertations.umi.com/northwestern:16378
-
- Description:
- The excitation of seismic waves depends on the geologic processes of an earthquake. The waveforms at seismic stations can be modeled as linear combinations of derivatives of Green's functions, which describe the response at the receiver location due to excitation at the seismic source location considering wave propagation effects given...
- Keyword:
- Moment Tensors, Moment Tensor Inversion, Seismic Source Processes, Non-Double-Couple Components, Big Data Analysis, and Moment Tensor Catalogs
- Subject:
- Geophysics
- Creator:
- Rösler, Boris
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_938604 and http://dissertations.umi.com/northwestern:16317
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- Description:
- Dopamine neurons are characterized by their response to unexpected rewards, but some also fire during movement and in response to aversive stimuli. Dopamine neuron diversity has also been observed based on their genetic expression profiles, suggesting that different functions might map onto such genetic subtypes. However, this has not been...
- Keyword:
- Subtypes, Striatum, Dopamine, and SNc
- Subject:
- Neurosciences
- Creator:
- Azcorra, Maite
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16371 and etdadmin_upload_947134
-
- Description:
- La Cotidianidad en la novela gráfica latinoamericana del siglo veintiuno investiga los elementos que conectan a la primera generación de artistas latinoamericanos del cómic que publican su arte principalmente en novelas gráficas, especialmente en relación con el uso de representaciones de la vida cotidiana en la región como principal motor...
- Keyword:
- Chile, Latin America, Graphic Novel, Brazil, Comics, and Colombia
- Subject:
- Literature
- Creator:
- Perez-Zayas, Ivan
- Owner:
- Scholarly Digital Publishing
- Language:
- es
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16366 and etdadmin_upload_946964
-
- Description:
- Biomineralization relies on the regulation of localized environments to control how minerals are formed. Through the use of confinement and specific additives, the organism is able to change the energy landscape of nucleation and growth to build single crystals with unusual morphologies. In order to better understand the environments in...
- Subject:
- Materials Science
- Creator:
- Duggins, Danielle
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_937458 and http://dissertations.umi.com/northwestern:16309
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- Description:
- From the 1990s through the 2000s, gross-out comedy – in the broadest terms, the style of physical comedy that emphasizes bodily functions and fluids, transgressive imagery and behavior, and shock value and disgust – triumphed as a subgenre of popular narrative film and television comedy. Gross-out comedy first emerged as...
- Keyword:
- disgust, irony, film comedy, and TV comedy
- Subject:
- Film studies
- Creator:
- Aspray, Benjamin Kole
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_944524 and http://dissertations.umi.com/northwestern:16341
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- Description:
- External manipulation of soft matter underlies a multitude of advancements in far-from-equilibrium materials. The application of magnetic fields has proven tremendouslybeneficial due to its ability to impart rapid and precise changes throughout soft magnetic systems. This has led to scientists and engineers to develop composite materials that take advantage of...
- Keyword:
- dynamic magnetic fields, simulations, soft matter, membranes, theory, and superparamagnetism
- Subject:
- Computational physics
- Creator:
- Brisbois, Chase
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16357 and etdadmin_upload_946183