This dissertation presents an affect-centered approach to the analysis and interpretation of the experience of music and its attendant meaning in selected works of literature and cinema. Music’s interpretative mutability often charges it with meaning, though in infinite gradations of singularity rather than any universal sense. Rather than undertake a...
Vertebrate brains evolved to facilitate a diverse array of behaviors and internal cognitive processes. Theories of neural function have proposed that neural computation is organized within populations or ensembles of neurons. Here, we identify ensembles of neurons in the striatum, the main input nucleus of the basal ganglia, in which...
This dissertation studies three markets with regulated prices. I focus on how these regulations shape the behavior of firms along non-price dimensions. Chapter 1 studies the effects of community rating regulations in the US individual health insurance exchange market. In this market, the Affordable Care Act established community rating areas...
The dissertation project considers the generative possibilities to envision Black subjectivity that emerges from a sustained consideration of different forms of difficult racial and sexual intimacies. The artists whose work is engaged throughout the project, Leasho Johnson, Ajamu X, and NIC Kay recognize that to be Black is to always...
Chapter 1. Caste, Bureaucracy, and the Limits to Political Affirmative Action. The aim of political affirmative action policies is to ensure that disadvantaged groups are represented in their governments and, in turn, that laws preferred by this group are more likely to be instituted. Often, however, they have not been...
Human olfactory function is important for a myriad of behaviors, including food seeking, social cognition, memory, emotional regulation, and detecting environmental threats. In animal models, particularly dense olfactory inputs have been shown to target orbitofrontal cortex (OFC), a region involved in multimodal sensory integration, reward coding, and flexibly guiding our...
In the first part of the thesis we,given a dg-Lie algebra $\g$, a commutative
dg-algebra $A$ and a twisting cochain $\mu$ in
$A \otimes \g$, we construct a map
from the functor of curved deformations of $\g$ to the
functor of curved deformations of the twisted tensor product
$A \otimes_\mu...
Neuroblastoma is one of the most common childhood cancers with one of the lowest survival rates, accounting for 15% of childhood cancer mortality. Approximately 15% of patients do not respond to initial treatment, and about half of children treated for high-risk neuroblastoma will relapse following remission. Ionizing radiation has long...
Amyloid beta oligomers (AβOs) are a key instigator of neurodegeneration in Alzheimer’s disease (AD). The work presented in this thesis includes three disease-modifying approaches to disrupt pathological AβO-related mechanisms in AD: (1) inhibiting AβO buildup, (2) blocking AβO-induced tau phosphorylation, and (3) neutralizing AβOs. These three approaches were tested in...
Technology that processes text, audio and video, as well as location data, has revolutionized many industries by enabling innovative operations for customer retention. To retain transactions for a platform and viewers for advertisers, this dissertation leverages novel digital tools to analyze consumer behavior, proposes original economic frameworks to guide platform...