Digitization has led to dramatic cost reductions and reshaped both what and how products are sold. This dissertation examines the impact of digitization on the behavior of market intermediaries that bring together producers and consumers. Our empirical context is the transition from 35mm film to digital cinema technologies in the...
Inflammasomes are intracellular multiprotein signaling complexes that link Pathogen Associated and Danger Associated Molecular Patterns (PAMPs and DAMPs) by Pattern Recognition Receptors (PRRs) to the activation of Caspase-1, leading to the secretion of pro-inflammatory cytokines interleukin (IL)-1β and IL-18, and the induction of pyroptosis. Nucleotide-binding oligomerization domain (NOD)-like containing a...
Excess loading of reactive nitrogen and phosphorus into the environment from human activities has resulted in widespread eutrophication and the degradation of surface water quality and wildlife habitat. Wastewater is the dominant point source of nutrient loading into waterways, and thus represents a critical opportunity for treatment and prevention of...
This project centers set design as the primary aesthetic, economic, and sociopolitical driver of the sitcom genre’s emergence and development during the first half of the twentieth century. My work treats sitcom set design as a category of historical architecture that can be (and has been) mapped, toured, built, and...
This dissertation contains three essays. In the first essay, "The Role of Connections in Congressional Lawmaking", I investigate the role of connections in congressional lawmaking by studying how legislators' deaths impact their peers' capacity to sponsor and advance bills in the U.S. House of Representatives. I focus on legislators who...
Gaussian process provides a principled and flexible approach for modeling the response surface or the latent function in many areas, including machine learning, statistics and computer experiment. In literature, Gaussian process models have already demonstrated their effectiveness and usefulness in a variety of applications. In this dissertation, we mainly focus...
Although flowing granular materials have been formally studied for over two hundred years, their behavior is still poorly understood relative to fluids, solids, and gases. Sheared granular materials with differing particle properties (e.g., size, density, shape) segregate (de-mix) due to percolation (small particles fall between large ones) and buoyancy (light...
Respiratory-swallow coordination is implicated as an essential component of safe and efficient swallowing, yet current evidence is incomplete regarding its relevance to swallowing impairment, assessment and treatment. Three studies were conducted that: 1) characterized and confirmed the optimal respiratory-swallowing coordination patterns in healthy adults, 2) identified linkages between deviations in...
This dissertation is on daily policing dynamics in China, centering around one core question: why coercive institutions can be extremely efficient for some issues but nearly dysfunctional for others in authoritarian regimes. The police may enforce the law relentlessly in some cases, even if there is no clear harm, but...
Agency is a broad orientation aimed to advance the self and one’s own abilities, whereas communion is a broad orientation aimed to interact with others and connect to people in a larger social context. In Chapter 1, I introduce a new framework to conceptualize the constructs of agency and communion....