Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Small, soluble, self-assembling peptide Aβ-oligomers, known as ADDLs (amyloid-derived diffusible ligands), accumulate in the Alzheimer’s disease (AD) brain as Aβ 12-mers and are thought to contribute to AD neuropathological conditions. Unlike plaques, which were once thought to cause neuronal death due to insoluble amyloid plaque deposits, ADDLs initiate abnormal changes...
Keyword:: Volume 6
Creator:: Thomas J. Meade, Rachel L. Pantoja, Amanda L. Eckermann, and Kylie D. Barker
Owner:: Scholarly Digital Publishing
Date Uploaded:: 07/23/2018
Date Modified:: 07/23/2018
Date Created:: 2009
Resource Type:: Article

Description:: In this study, ligands modified to contain a metal ion were synthesized and their electrochemical properties were examined alone and in the presence of a protein. We chose to use avidin and biotin as a model system. Probes have been developed in which biotin is modified to coordinate to a...
Keyword:: Volume 3
Creator:: Thomas J. Meade, Amanda L. Eckermann, and Charlotte A. Mason
Owner:: Scholarly Digital Publishing
Date Uploaded:: 07/17/2018
Date Modified:: 07/17/2018
Date Created:: 2006
Resource Type:: Article

Description:: Weak interactions in ligand-receptor pairs are important in biological systems. However, the energetics of these interactions are often difficult to quantify for ligandreceptor pairs. Weak interactions are a part of reorganization energy, which plays a role in electron transfer reactions. Under certain conditions the rate of electron transfer can be...
Keyword:: Volume 3
Creator:: Thomas J. Meade, Daniel J. Feld, Amanda L. Eckermann, and Kylie D. Barker
Owner:: Scholarly Digital Publishing
Date Uploaded:: 07/17/2018
Date Modified:: 07/17/2018
Date Created:: 2006
Resource Type:: Article

Description:: Electron transfer theory predicts reorganization energy to be one factor that determines the electrochemical potential of a metal ion. This paper describes part of a study that aims to increase understanding of solvent reorganization energy in noncovalent systems by systematically varying the environment around a metal ion, specifically ruthenium. The...
Keyword:: Volume 2
Creator:: Thomas J. Meade, Amanda L. Eckermann, and Charlotte A. Mason
Owner:: Scholarly Digital Publishing
Date Uploaded:: 07/16/2018
Date Modified:: 07/16/2018
Date Created:: 2005
Resource Type:: Article

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