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Modeling Posttraumatic Stress Disorder in a Genetic Rat Model of Depression

Description:

Posttraumatic stress disorder (PTSD) is an anxiety disorder characterized by flashbacks of the traumatic event and high comorbidity with major depressive disorder (MDD). Prior stress is known to increase the likelihood of developing PTSD after experiencing a traumatic event. Currently, PTSD is diagnosed clinically, its biological etiology is not known...

Keyword:

stress-enhanced fear learning, Genetic model of depression, contextual fear conditioning, Corticosterone, Post-Traumatic Stress Disorder, Rats, mineralocorticoid receptor, and Glucocorticoid receptor

Subject:

Neuroscience

Creator:

Lim PH, Redei EE, and Sophia Jenz

Owner:

Scholarly Digital Publishing

Date Uploaded:

06/13/2018

Date Modified:

06/13/2018

Date Created:

2018-05-31

Resource Type:

Poster
Prior Stress and Fear Conditioning Intensity Interact to Generate Sex-, and Strain-Specific Enhanced or Attenuated Fear Memory

Description:

In humans, posttraumatic stress disorder (PTSD) is co-morbid with major depressive disorder. Individuals who are exposed to stress prior to a traumatic event have an increased likelihood of developing PTSD. To study this increased vulnerability, a rat model was developed using the Stress Enhanced Fear Learning (SEFL) paradigm. This study...

Keyword:

Genetic model of depression, Post-Traumatic Stress Disorder, Contextual fear conditioning, Stress-enhanced fear learning, Corticosterone Glucocorticoid receptor, and Rats

Creator:

Przybyl KJ, Jenz ST, Redei EE, and Lim PH

Owner:

Scholarly Digital Publishing

Date Uploaded:

06/03/2019

Date Modified:

06/03/2019

Date Created:

6/1/2019

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Modeling Posttraumatic Stress Disorder in a Genetic Rat Model of Depression

Prior Stress and Fear Conditioning Intensity Interact to Generate Sex-, and Strain-Specific Enhanced or Attenuated Fear Memory

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