This paper investigates the use of self-assembled monolayers
(SAMs) to optimize the localized surface plasmon resonance (LSPR)
biosensor for disease detection. Various experiments were done
with 1-(9-mercaptononyl)-3,6,9-trioxaundecan-11-ol (TDT) and
heptaoxatricosanoic acid (HSA), a new SAM; these included a solvent
study to determine refractive index sensitivity and nonspecific binding
Many studies have focused on harnessing
the extraordinary optical properties of
noble metal nanoparticles for the development
of biological and chemical nanosensors.
Metallic nanoparticles emulate
surface roughness, facilitating the coupling
of light to surface plasmon polaritons. The
excitation of the plasmons enhances the
electromagnetic field near the surface so
This work exploits the use of noble metal
nanoparticles to achieve sensitive and
selective detection of chemical and
biological analytes. The localized surface
plasmon resonance (LSPR) of these metal
nanoparticles is known to be sensitive to
shape, size, and the local environment.
Ag nanoparticles fabricated using the
nanosphere lithography (NSL)...