Northwestern University

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Filtering by: Creator Sarita Lagalwar Resource type Dissertation

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Neurofibrillary tangles and granulovacuolar degeneration bodies: Examining protein aggregation and accumulation

Description:

Neurofibrillary tangle (NFT) formation in Alzheimer's disease (AD) and tauopathies occurs when tau protein adopts secondary structure and self-aggregates within neurons. Accompanying NFT maturation are post-translational modifications to tau; hyperphosphorylation, truncation and conformational changes occur in a highly sequential manner. In contrast, granulovacuolar degeneration bodies (GVDs) are a second type...

Keyword:

granules, p-SAPK/JNK, tau, and tangles

Subject:

Neuroscience Institute Graduate Program

Creator:

Sarita Lagalwar

Owner:

Scholarly Digital Publishing

Date Uploaded:

05/14/2018

Date Modified:

05/14/2018

Date Created:

2007-02-19

Resource Type:

Dissertation