Electron transfer theory predicts reorganization energy to be one factor that determines the electrochemical potential of a metal ion. This paper describes part of a study that aims to increase understanding of solvent reorganization energy in noncovalent systems by systematically varying the environment around a metal ion, specifically ruthenium. The...
Weak interactions in ligand-receptor
pairs are important in biological systems.
However, the energetics of these interactions
are often difficult to quantify for ligandreceptor
pairs. Weak interactions are a part
of reorganization energy, which plays a role
in electron transfer reactions. Under certain
conditions the rate of electron transfer
In this study, ligands modified to contain
a metal ion were synthesized and their
electrochemical properties were examined
alone and in the presence of a protein. We
chose to use avidin and biotin as a model
system. Probes have been developed in
which biotin is modified to coordinate to
Small, soluble, self-assembling peptide Aβ-oligomers, known as ADDLs
(amyloid-derived diffusible ligands), accumulate in the Alzheimer’s
disease (AD) brain as Aβ 12-mers and are thought to contribute to AD
neuropathological conditions. Unlike plaques, which were once thought
to cause neuronal death due to insoluble amyloid plaque deposits,
ADDLs initiate abnormal changes...