Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Immune checkpoint inhibitors have not been effective for immunologically “cold” tumors, such as prostate cancer, which contain scarce tumor infiltrating lymphocytes. We hypothesized that select tissue-specific and immunostimulatory bacteria can potentiate these immunotherapies. Here we show that a patient-derived prostate-specific microbe, CP1, in combination with anti-PD-1 immunotherapy, increased survival and...
Keyword:: Cancer
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Jonathan Forrest Anker
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/22/2019
Date Modified:: 04/22/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Description:: Post-transcriptional gene silencing (PTGS) and, more specifically, RNA interference (RNAi) include the processes by which a small double-stranded RNA, 19 to 22 nucleotides (nts) long, negatively regulates the expression and/or translatability of a target RNA, which harbors reverse complementarity to that small RNA, by recruiting the so-called RNA-Induced Silencing Complex...
Keyword:: siRNA, RNA Interference, Cell Death, Cancer, shRNA, and DISE
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: William Edward Putzbach
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/01/2019
Date Modified:: 04/01/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Description:: SIRT3 is a mitochondrial-localized, NAD+-dependent deacetylase, tumor suppressor protein that functions to direct mitochondrial energy sensing and antioxidant proteins, increasing the efficiency of energy utilization, providing a redox balanced environment, and preventing aging-related diseases. One SIRT3 deacetylation target is NADP+-dependent isocitrate dehydrogenase 2 (IDH2), a key Krebs Cycle enzyme that...
Keyword:: MnSOD, IDH2, Cancer, and Sirtuins
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Xianghui Zou
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/13/2018
Date Modified:: 04/13/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

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