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Description:: In vivo, substantia nigra pars compacta (SNc) dopaminergic neurons exhibit three spiking patterns – irregular, regular, and bursting. These distinct modes of activity are thought to underlie the different roles that dopamine (DA) plays in target structures within the basal ganglia. In particular, burst spiking in SNc DA neurons is...
Keyword:: burst firing, pedunculopontine nucleus, substantia nigra pars compacta, dopamine, and glutamate
Subject:: Interdepartmental Neuroscience Program (NUIN)
Creator:: Daniel James Galtieri
Owner:: Scholarly Digital Publishing
Date Uploaded:: 01/16/2019
Date Modified:: 01/16/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

Description:: The floor plate (FP) is a ventral midline organizing structure of the developing neural tube that provides positional information using morphogen concentration gradients towards the production of diverse neuron types. In caudal regions the FP is non-neurogenic unlike the mesodiencephalic region of the FP that is highly neurogenic, and is...
Keyword:: boundary, Premammillary, Engrailed, Floor plate, Subthalamic, and dopamine
Subject:: Interdepartmental Neuroscience Program (NUIN)
Creator:: Navid Nouri
Owner:: Scholarly Digital Publishing
Date Uploaded:: 03/30/2018
Date Modified:: 03/30/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

Description:: Dopaminergic neurons in the substantia nigra pars compacta are richly innervated by GABAergic neurons. The postsynaptic effects of GABA on SNc DA neurons are mediated by a mixture of GABAA and GABAB receptors. Although activation of GABAA receptors inhibits spike generation, the consequences of GABAB receptor activation are less well...
Keyword:: gabab, pka, substantia nigra, dopamine, and sk channel
Subject:: Interdepartmental Neuroscience Program (NUIN)
Creator:: Chad Michael Estep
Owner:: Scholarly Digital Publishing
Date Uploaded:: 03/22/2018
Date Modified:: 03/22/2018
Date Created:: 2016-01-01
Resource Type:: Dissertation

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