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Mapping the Mouse Nucleosome Landscape through Chemical Biology

Description:

Nucleosome organization influences gene activity by controlling DNA accessibility to transcription machinery. In this thesis, we have developed a chemical biology approach to determine mammalian nucleosome positions genome-wide. Using this strategy, we uncover surprising new features of nucleosome organization in mouse embryonic stem cells. In contrast to the prevailing model,...

Keyword:

histones, nucleosomes, epigenetics, chromatin, and transcription regulation

Subject:

Interdepartmental Biological Sciences (IBiS) Graduate Program

Creator:

Lilien Voong

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/26/2018

Date Modified:

01/29/2019

Date Created:

2017-01-01

Resource Type:

Dissertation