Protein-protein interactions are ubiquitous in living systems, and mediate important cellular processes from decision making to immunity against pathogens. Furthermore, protein-protein interactions are key to many protein therapeutics, pathogen diagnostics, and numerous synthetic biology applications. As a result, there has been significant effort to develop methods to express potential protein...
In 2009, the Health Information Technology for Economic and Clinical Health Act (HITECH) promoted national use of electronic health records (EHR) in the US by giving incentives to providers who adopt ‘meaningful use’ of EHRs. As of 2017, nearly 86% of office-based physicians had adopted EHRs. EHRs have rich information...
Preterm birth (PTB) is the leading cause of infant morbidity worldwide. Approximately 380,000 babies are born prematurely in the USA every year. Estrogen (E2) and progesterone (P4) play essential roles during pregnancy and labor; a clear understanding of their action mechanisms, however, is lacking. E2 and P4 function by activating...
This dissertation examines anti-Black race-based ideologies prevalent in early American musical theatre through a multi-faceted case study concerning Morgan Benson, a child actor of the early musical theatre stage, Target Parades of the long nineteenth-century, and The Black Joke. This is an excavation project, seeking to unearth conceptual underpinnings for...
Nuclear receptors (NRs) are an important family of transcription factors that often regulate genes in response to ligands and by way of direct interactions with coactivator proteins. Many NR-coactivator pairs have been identified that cooperate to regulate transcription but fully understanding how NRs recruit specific coactivators involves learning which of...
Research over the past several decades has revealed that memory reactivation in sleep contributes to the formation of long-lasting memories. Among the most recent developments in this field is the widespread use of the technique of targeted memory reactivation (TMR), which allows researchers to induce reactivation of specific memories during...
Contemporary decolonial criticism and critical phenomenological thought may be characterized as proceeding from a disenchantment with the philosophical aspiration towards universality. The overarching argument put forward in this dissertation is that there is, to the contrary, an intimate and even necessary connection between the decolonization of philosophy and the affirmation...
New capabilities in x-ray microscopy have been enabled by rapid advances in synchrotronlight sources and in high performance computing. We present here conceptual and computational
advances in two areas of x-ray microscopy. One involves ptychography, where computation is
used to obtain images from diffraction patterns as a finite coherent illumination...
Polymer and polymer/ceramic composites known as bone cements are commonly used in musculoskeletal reconstructive surgeries where bone tissue fixation, reinforcement, or void filling may be needed. Polymethylmethacrylate, PMMA, was the initial (and currently only) FDA-approved bone cement for bone-void filling applications yet faces many inherent material-based challenges that impacts its...
This dissertation analyzes how suburban school districts made sense of and planned to reduce inequality between 2019–2021. Previous literature has found that suburban schools, despite their reputation as the best in the country, are deeply unequal (Lewis and Diamond 2015; Lewis-McCoy 2014). Building on this previous scholarship, I ask: How...
Rising social inequality across economic, gender, and racial lines is a pressing issue of our time. Despite widespread agreement that inequality exists, there are stark ideological disagreements about its extent, its victims, and about what – if anything – should be done to address it. Prior work demonstrates that the...
Photochemistry is an inherently interdiscplinary field where very large energies are leveraged for the making and breaking of bonds. My work has broadly dealt with various strategies to control how energy delivered by light can be channeled into useful functions. I developed a strategy to control the chemo- and stereo-selectivity...
Breakthroughs in large-scale biological data collection have resulted in a wealth of -omics (genomics, metabolomics, etc.) datasets in the literature. However, the development of appropriate computational techniques for their analysis is lacking, yet crucial for fully extracting the rich information contained in these datasets. The work in this dissertation describes...
Cuteness is a popular aesthetic in product design, yet there is a lack of understanding of who is most likely to engage in cute consumption and, more importantly, why. In this dissertation, I consider the role of sex and gender identity in cute consumption, proposing a strong mental association between...
The answer to the question “Why do we sleep?” lies in understanding the biological underpinnings of homeostatic drive to sleep. Wakefulness is correlated with numerous changes in brain activity, structure and gene/protein expression that re-normalize following sleep however which of these elements is sufficient to cause sleep drive and how...
Perturbations to the physiology or impairments in the formation of synapses within the cochlea, specifically the ribbon synapses, result in decreased sensitivity to auditory stimuli. In example, prolonged exposure to moderately intense auditory stimuli, like power tools, can result in the swelling of nerve terminals, retraction of the postsynaptic membrane,...
The provision of social services is becoming increasingly complex as human service agencies, nonprofits, and government agencies recognize the importance of wraparound care. A wraparound approach to social service provision acknowledges the importance of providing comprehensive services that meet various individual, family, and community needs. This approach is enacted through...
Electrical spinal cord stimulation is an emerging treatment for spinal cord injury that can improve walking and bladder control, among many other functions. While the anatomical location of the motor pools for muscles involved in locomotion in the lumbosacral cord has been identified, the map of the functional output of...
For some inducible genes, the rate and molecular mechanism of transcriptional activation depend on the prior experiences of the cell. This phenomenon, called epigenetic transcriptional memory, accelerates reactivation, and requires both changes in chromatin structure and recruitment of poised RNA polymerase II (RNAPII) to the promoter. A well-established model for...
This dissertation contains two topics. The first topic focuses on how to use information design to minimize costs of implementing a policy that guarantees 100% passing rate of all participants by providing enough compensation for the their effort. The second topic explores an auction setting which involves financially distressed business...