Throughout a synthetic organic chemist’s career, reaction planning, execution, and analysis will be repeated countless times. The objective of my thesis research was to expedite this workflow to more efficiently access to novel, complex, and biologically useful molecules and synthetic methods. Since the mid 20th century there have been several...
Thermoelectric devices utilize semiconducting n-type and p-type thermoelectric materials to convert heat into electricity. Despite their promise for deep space power generation or waste heat recovery, most high-performing thermoelectric materials reported in literature are absent in practical applications - partially due to inconsistent synthesis and poor mechanical performance. This work...
Although research has shown LGBTQ+ youth are overrepresented in counts of homeless youth, scholars have yet to investigate whether this trend exists among adults experiencing homelessness. This dissertation uses an organizational analysis of four Chicago homeless centers that cater to young adults to argue that most LGBTQ+ youth are not...
When first-year students begin college they are thrown into a new environment where they are expected to simultaneously perform academically, form new relationships, and become independent. Many students struggle with this transition; experiences of stress, anxiety, and depression are common. For the majority of residential college students this is their...
Throughout the second half of the twentieth century, the United States expanded the scale, funding, and technological sophistication of its defense resources, enabling its current standing as the dominant global military superpower. This dissertation examines the role that the popular narrative genre of science fiction played in shaping American cultural...
Nucleic acid therapeutics can be drug molecules with high programmability, minimal off-target effects, and the capability to address “undruggable” targets for diseases. In addition, each time a new drug is needed, one needs to only change the sequence as opposed to finding an entirely new structure. One nucleic acid type...
As much as half of the gas mass in our Galaxy's dark matter halo may reside not in the galaxy itself, but in the surrounding volume, the circumgalactic medium (CGM). The vast gas content of the CGM, loosely defined as the volume immediately outside the galaxy but inside the dark...
South Africa’s rates of mental, neurological, and substance use disorders are among the highest in sub-Saharan Africa. In 2016, the estimated 12-month prevalence for any psychiatric disorder was 16.2%, or approximately 9.1 million individuals. Despite these elevated rates of psychiatric morbidity, access to mental health treatment is poor: only 27%...
This dissertation project uses both quantitative and qualitative analytical approaches to examine the dynamics of responsible investing in financial markets. The first chapter investigates how the institutionalization of responsible investing as a business strategy affects category claims made by mutual funds. The study finds that as the divestment movement in...
This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...