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Developmental biology
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- Description:
- The reprogramming of somatic cells to a spontaneously contracting cardiomyocyte-like state using defined transcription factors has proven successful in mouse fibroblasts. However, this process has been less successful in human cells, thus limiting the potential clinical applicability of this technology in regenerative medicine. We hypothesized that this issue is due...
- Keyword:
- calcium cycling, spontaneous contraction, high-throughput, cardiomyocyte, direct reprogramming, and fibroblast
- Subject:
- Biology, Cellular biology, and Developmental biology
- Creator:
- Romero Tejeda, Marisol
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_970274 and http://dissertations.umi.com/northwestern:16446
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- Description:
- One of the fundamental questions in developmental biology is how a single cell gives rise to a complex organism. More specifically, how a totipotent egg divides into cells that become increasingly restricted in their potential. Development is a process of increasingly restricted cellular potential, and here I home in on...
- Keyword:
- Xenopus, Pluripotency, Neural Default Model, BMP, Smads, and Activin
- Subject:
- Biology and Developmental biology
- Creator:
- Johnson, Kristin Lorette
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16347 and etdadmin_upload_945075
-
- Description:
- Dopamine (DA) neurons are involved in many brain functions, and their dysfunction is associated with several neurodegenerative diseases. In recent years, our lab and others have found that DA neurons are molecularly diverse through single-cell gene expression profiling. An outstanding question in the field is whether this heterogeneity is encoded...
- Subject:
- Developmental biology
- Creator:
- Pereira Luppi, Maria Milagros
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16348 and etdadmin_upload_945123
-
- Description:
- Preterm birth (PTB) is the leading cause of infant morbidity worldwide. Approximately 380,000 babies are born prematurely in the USA every year. Estrogen (E2) and progesterone (P4) play essential roles during pregnancy and labor; a clear understanding of their action mechanisms, however, is lacking. E2 and P4 function by activating...
- Keyword:
- progesterone receptor, estrogen receptor, labor, genome-wide, ChIP-Seq, and RNA-Seq
- Subject:
- Obstetrics, Cellular biology, and Developmental biology
- Creator:
- Dotts, Ariel Janiece
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_908705 and http://dissertations.umi.com/northwestern:16117
-
- Description:
- Pattern formation of biological structures involves the arrangement of different types of cells in an ordered spatial configuration. Patterning is thought to involve the spatial organization of molecular pre-patterns that precede and drive subsequent cell differentiation and coinciding morphogenesis. These molecular prepatterns are often, although not exclusively, organized through Turing...
- Keyword:
- emergence, compound eye, self organization, Drosophila, morphogenesis, and pattern formation
- Subject:
- Biology, Biophysics, and Developmental biology
- Creator:
- Gallagher, Kevin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16245 and etdadmin_upload_928342
-
- Description:
- Zinc, an essential trace element that serves as an enzyme cofactor and can also be stored as a divalent ion in cellular vesicles, is emerging as an important mediator of signaling pathways required for biological functions such as growth, development, and reproduction. Zinc mediates cell signaling by acting both as...
- Subject:
- Developmental biology
- Creator:
- Chen, Yu-Ying
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_879371 and http://dissertations.umi.com/northwestern:15933
-
- Description:
- Body size is one of the most discernible ways in which animal species vary. The blue whale (Balaenoptera musculus), the largest animal on earth, can reach up to 30 m in length and weigh up to 200 tonnes. At the other extreme, a species of frog called Paedophryne amauensis is...
- Subject:
- Genetics and Developmental biology
- Creator:
- Nyaanga, Joy
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16113 and etdadmin_upload_904655
-
- Description:
- Recent discoveries in vitamin D research indicate that vitamin D is a necessary component to several organs and tissues that extends beyond bone formation Furthermore, recent research indicates that vitamin D deficiency is rampant across the globe. Historically, anthropological research has focused on the adaptive significance of skin color to...
- Keyword:
- Philippines, developmental biology, Vitamin D, biological anthropology & human biology, gender & sex, and epigenetics
- Subject:
- Physical anthropology, Public health, and Developmental biology
- Creator:
- Perez, Julianna
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15568 and etdadmin_upload_818816
-
- Description:
- A variety of human diseases and pregnancy related disorders reflect endometrial dysfunction. However, rodent models do not share fundamental biological processes with the human endometrium, such as cyclic menstruation, and no existing human cell cultures recapitulate the cyclic interactions between endometrial stromal and epithelial compartments necessary for decidualization and implantation....
- Keyword:
- human endometrial organoid, pluripotent stem cells, epithelial-stromal signaling, cyclic hormone response, human endometrial stromal cells, and human decidua
- Subject:
- Biology and Developmental biology
- Creator:
- Chu, Virginia
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15366 and etdadmin_upload_776955
-
- Description:
- Cells are often precisely organized into patterns within developing tissues. This precision must emerge from biochemical processes within, and between cells, that are inherently stochastic. I investigated the impact of stochastic gene expression on self-organized pattern formation, focusing on Senseless (Sens), a key target of Wnt and Notch signaling during...
- Keyword:
- gene expression, microRNA, cell fate, Drosophila, self-organization, and noise
- Subject:
- Applied mathematics, Statistics, and Developmental biology
- Creator:
- Giri, Ritika
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_763812 and http://dissertations.umi.com/northwestern:15251
-
- Description:
- South Africa’s rates of mental, neurological, and substance use disorders are among the highest in sub-Saharan Africa. In 2016, the estimated 12-month prevalence for any psychiatric disorder was 16.2%, or approximately 9.1 million individuals. Despite these elevated rates of psychiatric morbidity, access to mental health treatment is poor: only 27%...
- Keyword:
- trauma , mental health, biological anthropology & human biology, South Africa, prenatal stress, and hypothalamic-pituitary-adrenal axis
- Subject:
- Epidemiology, Mental health, and Developmental biology
- Creator:
- Kim, Andrew Wooyoung
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15411 and etdadmin_upload_780918
-
- Description:
- Melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs) represent a class of non-canonical, ganglion cell photoreceptors. These cells influence a variety of visual behaviors including contrast sensitivity, circadian photoentrainment, sleep, and even mood. These wide-ranging behavioral influences are attributed to the multiple subtypes (M1-6) that comprise the ipRGC population, with different...
- Keyword:
- Development, ipRGCs, Melanopsin, and Retina
- Subject:
- Neurosciences and Developmental biology
- Creator:
- Lucas, Jasmine Ashley
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_744013 and http://dissertations.umi.com/northwestern:15132
-
- Description:
- Proper spatiotemporal expression of genes is essential during development. One method of regulation of signaling-responsive genes is at the level of transcription. In this work, I present the adaptation of single molecule fluorescent in situ hybridization for use in Drosophila imaginal disc tissues in order to more precisely quantify transcript...
- Keyword:
- gene expression, transcription, microscopy, bursting, in situ hybridization, and drosophila
- Subject:
- Systematic biology, Biology, and Developmental biology
- Creator:
- Bakker, Rachael
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15416 and etdadmin_upload_780973
-
- Description:
- Animals must establish the correct form during development. Regeneration is a process by which some animals reestablish their form following injury. This process requires both the generation of new missing cells after injury, and information to pattern new cells to reestablish the correct form. Planarian flatworms have an almost unlimited...
- Keyword:
- planaria, Regeneration, size control, neoblasts, stem cells, and scaling
- Subject:
- Molecular biology and Developmental biology
- Creator:
- Schad, Erik Gregory
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14973 and etdadmin_upload_715415
-
- Description:
- Organismal development depends upon countless cell decisions to adopt particular fates at the appropriate time and place. These decisions are executed by systems of biochemical reactions called regulatory networks. Elucidating the general principles underlying the structure and function of these networks is vital to understanding all developmental processes, as well...
- Keyword:
- Development, Quantitative Biology, Cell Decisions, Mosaic Analysis, Drosophila, and Metabolism
- Subject:
- Chemical engineering and Developmental biology
- Creator:
- Bernasek, Sebastian Michal
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_663067 and http://dissertations.umi.com/northwestern:14676
-
- Description:
- The embryonic neural crest is a unique vertebrate stem cell population that has the ability to retain its stem attributes while neighboring cells in the embryo undergo lineage restriction. These cells possess multi-germ layer developmental potential and can give rise to a diverse array of derivatives such as components of...
- Keyword:
- pluripotency, HDAC, Neural Crest, TSA, and stem cell
- Subject:
- Bioinformatics and Developmental biology
- Creator:
- Rao, Anjali Narsing
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_663294 and http://dissertations.umi.com/northwestern:14684
-
- Description:
- Neural crest cells are a population of multipotent stem cells that are unique to vertebrates and give rise to a wide range of derivatives in the developing embryo, including elements of the craniofacial skeleton, pigmentation of the skin and peripheral nervous system. Although these cells reside in the ectoderm, they...
- Keyword:
- Xenopus, SoxB1, pluripotency, SoxE, Stem Cells, and Neural Crest Cells
- Subject:
- Molecular biology and Developmental biology
- Creator:
- Buitrago-Delgado, Elsy Cristina
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_627223 and http://dissertations.umi.com/northwestern:14468
-
- Description:
- A fundamental goal in biology is to understand how distinct cell types containing the same genetic information arise from a single stem cell throughout development. Sex determination is a key developmental process that requires a unidirectional commitment of an initially bipotential gonad towards either the male or female fate. This...
- Keyword:
- enhancers, sex reversal, CBX2, chromatin, bivalent chromatin, and sex determination
- Subject:
- Developmental biology
- Creator:
- Garcia-Moreno, Sara A. Alexandra
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_616325 and http://dissertations.umi.com/northwestern:14397