Index Catalog // Arch : Northwestern University Institutional Repository

Plakophilin 2: Critical Roles in Intercellular Junction Assembly and Maturation via Regulation of Protein Kinase C and Actin

Description:: Desmosomes are adhesive complexes found at sites of intercellular contact that are essential for mediating cell-cell adhesion. These junctions undergo regulated assembly and reorganization during processes such as embryogenesis and wound healing. Plakophilins (PKPs) are armadillo family members related to the classic cadherin-associated protein p120ctn. PKPs localize to the cytoplasmic...
Keyword:: desmosome, cytoskeleton, cell-cell adhesion, armadillo, and plakophilin
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Amanda Elisabeth Bass-Zubek
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/20/2018
Date Modified:: 09/20/2018
Date Created:: 2008-09-18
Resource Type:: Dissertation

Analysis of Latent Membrane Protein (LMP) 2A Signaling Through Src Family Kinases and the Role of LMP2B in Modulating LMP2A Signaling

Description:: Latent membrane protein 2A (LMP2A) and LMP2B are viral proteins expressed during Epstein-Barr virus (EBV) latency in EBV-infected B cells both in cell culture and in vivo. Although Lyn has been shown to be important in mediating LMP2A signaling, it is still unclear if Lyn is used preferentially or if...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Mark Rovedo
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/18/2018
Date Modified:: 09/18/2018
Date Created:: 2008-09-03
Resource Type:: Dissertation

Mechanism of Nuclear Import of a Smooth Muscle Cell-Specific Plasmid Vector for Gene Therapy

Description:: Cardiovascular disease is a leading cause of morbidity and mortality worldwide. While many therapies have been used to treat vascular disease symptomatically, gene therapy offers a means of treating the molecular dysfunctions driving disease pathogenesis. Unfortunately, gene therapy has achieved only modest therapeutic success in clinical trials due to a...
Keyword:: nuclear import, karyopherins, plasmid, nuclear localization signal, and gene therapy
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Aaron Michael Miller
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/17/2018
Date Modified:: 09/17/2018
Date Created:: 2008-08-01
Resource Type:: Dissertation

Estrogen Neuroendocrine Feedback is Mediated Distinctly via Estrogen Response Element Dependent and Independent Estrogen Receptor Alpha Signaling

Description:: Gonadotropins LH and FSH are secreted by the pituitary in response to hypothalamic GnRH and act to stimulate ovarian follicle development, steroid production and ovulation. Gonadal steroids, including estrogen, enter the circulation and provide neuroendocrine feedback at the hypothalamus and/or pituitary. Estrogen provides negative feedback to suppress gonadotropin release throughout...
Keyword:: Neuroendocrinology, Non-classical, Estrogen, Classical, Nonclassical, and Reproduction
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Christine Ann Glidewell-Kenney
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/14/2018
Date Modified:: 09/14/2018
Date Created:: 2008-07-15
Resource Type:: Dissertation

Type II Secretion and Secreted Ppiases Promote Low Temperature Growth and Survival in Legionella pneumophila

Description:: PilD is an enzyme that processes prepilins that are part of the type II protein secretion apparatus and the type IV piliation machinery. Using a <em>Legionella pneumophila pilDlacZ</em> fusion strain to measure transcription, we observed a 20% increase in beta-galactosidase levels at 30°C vs. 37°C. At 25°C and 17°C vs....
Keyword:: Microbiology and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Maria Soderberg
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/06/2018
Date Modified:: 09/06/2018
Date Created:: 2008-03-25
Resource Type:: Dissertation

Glial activation links early-life seizures and increased susceptibility to seizures in adulthood</

Description:: Early-life seizures increase susceptibility to seizures in adulthood. However, mechanisms by which seizures in the developing brain lead to increased vulnerability to seizures and exacerbation of neurological injury in adulthood remain unknown. We test the hypothesis that upregulation of proinflammatory cytokine levels and chronic glial activation following early-life seizures result...
Keyword:: seizures, cytokines, microglia, glia, glutamate, and neuroinflammation
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Kathleen Cua Somera-Molina
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/27/2018
Date Modified:: 08/27/2018
Date Created:: 2007-12-07
Resource Type:: Dissertation

Functional Characterization of Epstein-Barr Virus gH/gL Glycoprotein Complex in Fusion

Description:: Epstein-Barr virus (EBV) is a human gamma-herpesvirus that primarily infects B cells and epithelial cells. While the glycoproteins required for entry into these two cell types differ, the gH/gL glycoprotein complex is essential for entry into both epithelial and B cells. Analysis of gH protein sequences from three gamma-herpesviruses: EBV,...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Jasmina Omerovic
Owner:: Scholarly Digital Publishing
Date Uploaded:: 06/05/2018
Date Modified:: 06/05/2018
Date Created:: 2007-05-09
Resource Type:: Dissertation

Microenvironment Regulation of Proteinase Expression and E-cadherin Ectodomain Generation in Ovarian Cancer

Description:: Most women diagnosed with epithelial ovarian carcinoma (EOC) initially present with metastases, but little is known about the regulation of ovarian tumor cell dissemination by the tumor microenvironment. Because ovarian cancer cell dissemination is mostly limited to the peritoneal cavity and often results in the accumulation of malignant ascites, the...
Keyword:: Biology and Cell
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Jaime Symowicz
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/21/2018
Date Modified:: 05/21/2018
Date Created:: 2007-03-12
Resource Type:: Dissertation

Derivation of Cardiomyocytes from Embryonic Stem cells and Development of Techniques to Study Cardiac Lineage

Description:: Embryonic stem cells have the potential to differentiate into ectodermal, mesodermal and endodermal derivatives. This property makes them a valuable source of tissue specific progenitor and differentiated cells that can be used for cell replacement therapy. The first goal of this thesis is to test if cardiogenesis from embryonic stem...
Keyword:: Cell Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Achuta K Guddati
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/08/2018
Date Modified:: 10/08/2018
Date Created:: 2008-05-09
Resource Type:: Dissertation

Luteinizing Hormone Receptor Signaling Regulates MAP2D Phosphorylation in Preovulatory Granulosa Cells

Description:: The actions of luteinizing hormone (LH) to induce ovulation and luteinization of preovulatory follicles are mediated principally by activation of cAMP-dependent protein kinase (PKA) in granulosa cells. PKA activity is targeted to specific cellular locations by A-kinase anchoring proteins (AKAPs). I previously showed that follicle-stimulating hormone (FSH) induces expression of...
Keyword:: cyloskeleton, MAP2, vimentin, ovary, granulosa cell, and luteinizing hormone
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Maxfield Patrick Flynn
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/03/2018
Date Modified:: 10/03/2018
Date Created:: 2008-08-11
Resource Type:: Dissertation

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Plakophilin 2: Critical Roles in Intercellular Junction Assembly and Maturation via Regulation of Protein Kinase C and Actin

Analysis of Latent Membrane Protein (LMP) 2A Signaling Through Src Family Kinases and the Role of LMP2B in Modulating LMP2A Signaling

Mechanism of Nuclear Import of a Smooth Muscle Cell-Specific Plasmid Vector for Gene Therapy

Estrogen Neuroendocrine Feedback is Mediated Distinctly via Estrogen Response Element Dependent and Independent Estrogen Receptor Alpha Signaling

Type II Secretion and Secreted Ppiases Promote Low Temperature Growth and Survival in Legionella pneumophila

Glial activation links early-life seizures and increased susceptibility to seizures in adulthood</

Functional Characterization of Epstein-Barr Virus gH/gL Glycoprotein Complex in Fusion

Microenvironment Regulation of Proteinase Expression and E-cadherin Ectodomain Generation in Ovarian Cancer

Derivation of Cardiomyocytes from Embryonic Stem cells and Development of Techniques to Study Cardiac Lineage

Luteinizing Hormone Receptor Signaling Regulates MAP2D Phosphorylation in Preovulatory Granulosa Cells

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