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Improving Biological Properties of Spherical Nucleic Acids Through Structural Control

Description:

Nucleic acid therapeutics can be drug molecules with high programmability, minimal off-target effects, and the capability to address “undruggable” targets for diseases. In addition, each time a new drug is needed, one needs to only change the sequence as opposed to finding an entirely new structure. One nucleic acid type...

Keyword:

RNAi, siRNA, gene therapy, structure-function, spherical nucleic acid, and nanoparticle

Subject:

Nanotechnology, Pharmaceutical sciences, and Biomedical engineering

Creator:

Vasher, Matthew Kuo

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/16/2023

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_938909 and http://dissertations.umi.com/northwestern:16319
Engineering the "Nanocarrier Chassis" for Targeted Drug Delivery: Controllable Multiscale Interactions for Immunomodulation and Glaucoma Therapy

Description:

Nanocarriers are drug delivery vehicles that have at least one dimension at the nanoscale (10-9 m). Engineering the nanocarrier surface is a strategy for targeting drug delivery to specific cell types to enhance efficacy and minimize side effects. A useful analogy is to consider how the chassis of an automotive...

Keyword:

Nanotechnology, Glaucoma, Immunomodulation, Protein Adsorption, Nanocarrier Chassis, and Targeted Drug Delivery

Subject:

Pharmaceutical sciences, Materials Science, and Biomedical engineering

Creator:

Vincent, Michael Patrick

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/02/2022

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15870 and etdadmin_upload_863441

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Improving Biological Properties of Spherical Nucleic Acids Through Structural Control

Engineering the "Nanocarrier Chassis" for Targeted Drug Delivery: Controllable Multiscale Interactions for Immunomodulation and Glaucoma Therapy

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