It is critical to genomic integrity that DNA is replicated completely and faithfully during each cell cycle. The essential replication factor Cdt1 is a critical protein in preventing reinitiation of replication. Overexpression of Cdt1 causes re-replication in p53 null cells and transforms NIH3T3 cells, causing them to form tumors in...
During the sixteenth and seventeenth centuries, many images of dwarves, hirsutes, and castrati depict them in the guise of the monstrous, either as jokes of nature or indices of courtly wit. However, there are some Renaissance portraits of physically deformed individuals that transcend these categories. These portraits point to the...
As technology moves into deep submicron and nanoscale era, undesirable trends such as increasing power density, leakage power, and temperature variation within chips have made thermal effects emerge as a major bottleneck in further technology scaling. Thermal effects are no longer considered as just a reliability issue, but it also...
In the first chapter, I study how political institutions can affect policymaking when the economy is in transition. I develop a framework where a transition process gradually restructures economic institutions so that the population's long-term preference may differ from its short-term preference. A democracy may fail to implement the optimal...
Next generation of high performance nano-optoelectronic integrated circuits will require an integral combination of highly efficient all-optical nanophotonic devices and electrically-pumped nanophotonic devices, which will enable the chip to process optical information all optically with ultrafast speed and electro-optically to interface with the electronic control plane. The realizations of such...
At the heart of nonlinear optimization methods lies the solution of linear systems of equations. As the size of the problem increases, it is imperative to use iterative methods, such as the conjugate gradient algorithm, to solve these linear systems. In the context of constrained optimization, it has proved to...
Entangled photons serve as an important tool in the field of quantum information processing. Traditionally, spontaneous parametric down-conversion (SPDC) in second-order nonlinear crystals has been the workhorse source for generating entangled photons. However, those SPDC-generated photons are notoriously difficult to couple into single-mode optical fibers due to mode mismatch, thus...
In "Optimal Delegation" I analyze the design of decision rules by a principal who faces an informed but biased agent and who is unable to commit to contingent transfers. The contracting problem reduces to a delegation problem in which the principal commits to a set of decisions from which the...
This dissertation examines topical humor produced by "Late Night with David Letterman," "The Tonight Show with Jay Leno," "Saturday Night Live," and The Onion for the period of one year after the terrorist attacks of September 11, 2001. Three phases emerge: the purgation of extreme emotions like anger, acceptance or...
This thesis is devoted to the study of A-branes on symplectic tori and to the Mirror Symmetry conjecture. Using a method called Seidel's mirror map, we are able to reconstruct the homogeneous coordinate ring of a complex abelian variety using Lagrangian intersection theory on the mirror symplectic torus. Moreover, we...
In composite manufacturing, Vacuum Assisted Resin Transfer Molding (VARTM) is becoming increasingly important as a cost effective manufacturing method of structural composites. In this process the dry preform (reinforcement) is placed on a rigid tool and covered by a flexible film to form an airtight vacuum bag. Liquid resin is...
This dissertation presents a Nuclear Magnetic Resonance (NMR) study of anisotropic superconductors, MgB$_2$ and Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$ (Bi2212), and diffusion in glass-forming aqueous solutions of glycerol. In glycerol and deuterated water mixtures, the diffusion of glycerol is measured selectively by the $^1$H NMR stimulated echo technique in the gradient field of a...
The primary function of the human urinary bladder is to store urine, while maintaining a permeability barrier that protects underlying tissues from noxious urinary components. Inflammatory diseases of the bladder, including urinary tract infection (UTI) and interstitial cystitis (IC), afflict millions of patients in the US annually and cause significant...
High relaxivity contrast agents are of great importance in the advancement of magnetic resonance imaging diagnostics for use in biomaterials. Biomaterials that are implanted into the body, with the goal of repairing or regenerating lost or damaged tissue, need to be tracked noninvasively, over time. I have completed work using...
Magnetic resonance imaging (MRI) allows for the selective visualization of blood vessels via the intravascular injection of a paramagnetic contrast agent and the suppression of background signal. Called magnetic resonance angiography (MRA), this technique can produce three-dimensional images and is useful clinically for the noninvasive diagnosis of vascular disorders. In...
What can the theatrical use of food accomplish in performances which assert cultural, legal, or moral rights to food production and consumption in a food insecure society? Case studies comprising the USDA's 1933-34 World's Fair exhibits, the May 1933 Wisconsin Cooperative Milk Pool protest, the 1936 Federal Theatre Project living...
"Prufrock" to <em>The Waste Land</em>: T. S. Eliot's Periodical Publications, 1915-1922 Randall J. Woods This dissertation presents, in publication date order, the 167 articles published by T. S. Eliot from 1915 to 1922, most of which have never been reprinted. They include literary criticism, book reviews, poetry, philosophical essays, humorous...
I study several aspects of a game-theoretic model of persuasion. A speaker attempts to persuade a listener to take an action which is highly ranked by the speaker. The listener knows the speaker's preference but is uncertain about what the speaker can say. The listener can commit to a persuasion...
Primary Progressive Aphasia (PPA) is an aphasic dementia syndrome caused by neurodegenerative disease in which linguistic abilities are selectively disrupted in the relative absence of other cognitive deficits in early stages. The studies presented in this thesis were designed to examine the integrity of word and object processing by contrasting...
Chinese television has gone through enormous growth and significant structural change since the economic reforms of the 1970s. The changes include an increased number of channels, the establishment of overseas channels, increased reliance on advertising, more diversified programming, and heightened market competition. The new multi-channel media environment has the potential...