Inter-organelle contact sites have become increasingly appreciated as important regulators of cellular homeostasis, and disruption of inter-organelle contact site dynamics and function has been observed in various pathologies. Recently, inter-organelle contact sites between mitochondria and lysosomes were discovered, offering a new mechanism by which these two organelles may directly interact,...
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and associated with increased risk for ischemic stroke and mortality. While the risk of stroke has been shown to be reduced with the use of oral anticoagulants like Warfarin, these medications are predictably linked with an increased risk of bleeding, and...
Pathogenic bacteria scavenge essential nutrients including metals, amino acids and peptides to survive within the hostile host environment. Bacteria utilize ATP-binding cassette (ABC) transporters, powered by the energy of ATP hydrolysis, to move substrates across cellular membranes. The substrate-binding protein (SBP) shuttles substrate in the periplasm and directs the substrate...
Sound is one of the most important mediums to understand the environment around us. Identifying a sound event in prerecorded audio (such as a police siren, a dog bark, or a creaking door in soundscapes) leads to a better understanding of the context where the sound events occurred. To do...
This dissertation investigates a number of models and algorithms in the context of optimization under uncertainty. The focus is on risk-averse optimization, where risk aversion is modeled via stochastic dominance, utility theory, and distributionally robust optimization. We first investigate an investment model with fixed contribution rates, optimize asset-allocation decisions in...
Supported vanadium oxide materials have been extensively studied for alkane oxidative dehydrogenation (ODH) reactions due to their high activity and selectivity. The catalytic activity of supported VOx materials is influenced by the surface coverage of VOx sites and hence the distribution of V=O, V-O-V, and V-O-S (S, support) bonds. The...
Active lateral force feedback is essential for haptic applications in which forces on the fingertip is perpendicular to or in the same direction of finger movement, such as virtual shape rendering and button click rendering. In this thesis, I first present a novel device, the UltraShiver, that can provide large...
In recent decades, mass loss from glaciers and ice caps (GICs) worldwide has accelerated, contributing significantly to the observed sea–level rise. Their continued melt is also expected to alter local hydrological systems, affecting freshwater availability and quality. Despite these problematic impacts, little is known about GIC variations prior to the...
Increasingly high global energy consumption demands effective approaches to high energy efficiency and, at the same time, paths to reduced release of carbon dioxide, a primary greenhouse gas behind global climate change. Friction reduction is a vital aspect towards making energy systems more efficient and one of the most crucial...
The investigation of ceria-related materials has a long history since 1920s. The first publication on web of science traces back to 1928. Ever since that, more studies come out and surge starting from 1987. This material has attracted extensive attention due to its wide applications in electrochemical devices, catalysis, and...
Polyolefins are the most versatile and widely used polymers worldwide. Depending on the polymer microstructure, polyolefins can exhibit a wide range of useful and tailored properties and applications. Metal-catalyzed coordinative olefin polymerization plays a center role in advancing polyolefin synthesis. This dissertation explores two strategies to modulate the polymer microstructures...
In this thesis I focus on two topics: planet-disk interaction and solar convection. These two seemingly separate topics are connected via a similar separation of timescales. Planets excite spiral waves in their disks on fast timescales compared to the time for the disk to viscously adjust to the angular momentum...
This thesis provides an introduction to decay rates for the damped wave equation on compact manifolds. It also gives a proof of a sharp decay rate for solutions to the damped wave equation on the torus with damping of a particular polynomial form. Finally it gives a proof of a...
How we remember, narrate and teach the past is an inherently political and ethical act. This is especially true when teaching about race and racism within the context of United States history. In this dissertation, I ask: how do young people narrate the durability of racial inequality in the United...
Despite its demonstrated effectiveness, exposure therapy – repeatedly approaching a fear/anxiety trigger – is not widely used in the treatment of anxiety disorders. This may be due to its image as an aversive (and even harmful) approach to treatment and its reduced rates of compliance among patients. However, if exposure...
The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative pathways, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. HK1 contains an N-terminal domain that permits mitochondrial binding, but its physiologic significance remains unclear. We generated mice lacking the HK1 mitochondrial-binding...
Digitization has led to dramatic cost reductions and reshaped both what and how products are sold. This dissertation examines the impact of digitization on the behavior of market intermediaries that bring together producers and consumers. Our empirical context is the transition from 35mm film to digital cinema technologies in the...
Students pursue educational and career future identities (e.g., graduating college, becoming an engineer, etc.) that are tied to their deepest wants, desires, and needs, yet many find it difficult to exert self-control and resist temptations while pursuing these identities (e.g., studying versus watching TV, paying attention in class versus scrolling...
This dissertation is a collection of three papers on synthesizing and translating statistical evidence in education research. Chapter 1 serves as an introduction and executive summary, and Chapters 2 - 4 contain the three substantive papers respectively. Chapter 2 presents methods for pooling sample variances across studies to improve properties...
We study modular forms, Jacobi forms, and hermitian formal Fourier-Jacobi series over imaginary quadratic fields. In the first section, we prove that the ring of classical Jacobi forms of a fixed genus g, varying index m and weight k is generated by theta functions. From this result we show that...
