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Description:: The brain is known to shrink in normal aging or neurodegenerative disease and yet the neurobiological underpinnings of the cortical atrophy remain elusive. The structural changes that represent cortical atrophy can be measured during life using the reliable and quantitative method known as magnetic resonance imaging (MRI). Primary progressive aphasia...
Keyword:: primary progressive aphasia, neurons, cortical atrophy, activated microglia, and Alzheimer's disease
Subject:: Pathology, Medical imaging, and Neurosciences
Creator:: Ohm, Daniel Timothy
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_640035 and http://dissertations.umi.com/northwestern:14532

Description:: In several neurodegenerative diseases, the microtubule-associated protein tau self-aggregates to form filaments that accumulate in neurons and/or glia, although the relationship between tau aggregation and cell death is a subject of debate. The amino terminus of tau is involved in conformational changes that appear critical for filament formation, hinting at...
Keyword:: filament, axonal transport, kinesin, Alzheimer's disease, and tau
Subject:: Neuroscience Institute Graduate Program
Creator:: Nichole LaPointe
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/06/2018
Date Modified:: 09/06/2018
Date Created:: 2008-02-21
Resource Type:: Dissertation

Description:: The polymerization of the microtubule-associated protein, tau, into insoluble filaments is common to Alzheimer's disease (AD) and in a variety of dementias. The conformational change required for tau to transition from soluble monomers to filamentous AD pathology involves the extreme N-terminus of tau coming into contact with other regions of...
Keyword:: Alzheimer's disease, tangle, N-terminus, frontotemporal dementia, and tau
Subject:: Neuroscience Institute Graduate Program
Creator:: Peleg Moshe Horowitz
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/07/2018
Date Modified:: 05/07/2018
Date Created:: 2006-11-16
Resource Type:: Dissertation

Description:: Patients with the Primary Progressive Aphasia (PPA) clinical syndrome have diverse forms of neuropathology, one of which is the cellular and molecular abnormalities of Alzheimer’s disease (AD), at post mortem autopsy. Structural anatomical differences might aid in ante mortem differential diagnosis of neuropathology. The studies in this dissertation investigated one...
Keyword:: Memory, Hippocampus, Neuropsychology,, Primary Progressive Aphasia, Alzheimer's disease, and Structural MRI
Subject:: Clinical Psychology
Creator:: Adam Christensen
Owner:: Scholarly Digital Publishing
Date Uploaded:: 02/19/2018
Date Modified:: 02/19/2018
Date Created:: 2016-01-01
Resource Type:: Dissertation

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