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The Regulation of Infection-Induced Cardiac Autoimmunity and Natural Dissemination of Trypanosoma cruzi in Experimental Chagas Heart Disease

Description:

Chagas heart disease, caused by infection with the protozoan parasite Trypanosoma cruzi, is still regarded as a major public health problem in Central and South America. The finding of cardiac specific autoimmunity during infection in both humans and experimental animals has provided a basis for investigation of its potential role...

Keyword:

Myosin, Trypanosoma cruzi, Luminescence, Autoimmunity, Chagas, and Cardiac

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Kenneth Vincent Hyland

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/14/2018

Date Modified:

09/14/2018

Date Created:

2008-11-10

Resource Type:

Dissertation
Dual Mechanisms for Antigen-Specific Peripheral Tolerance Induction as a Therapy for Experimental Autoimmune Encephalomyelitis

Description:

MHC class II-restricted T cell responses are a common driving force of autoimmune disease. Numerous therapeutic strategies target CD4+ T cells hoping to attenuate autoimmune responses and restore self-tolerance. We have previously reported that i.v. treatment with antigen-pulsed, ethylenecarbodiimide (ECDI)-fixed splenocytes (Ag-SP) is an efficient protocol to induce Ag-specific tolerance...

Keyword:

T cell, Autoimmunity, Multiple Sclerosis, Experimental Autoimmune Encephalomyelitis, and Tolerance

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Danielle Marie Turley

Owner:

Scholarly Digital Publishing

Date Uploaded:

08/28/2018

Date Modified:

08/28/2018

Date Created:

2007-12-07

Resource Type:

Dissertation

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The Regulation of Infection-Induced Cardiac Autoimmunity and Natural Dissemination of Trypanosoma cruzi in Experimental Chagas Heart Disease

Dual Mechanisms for Antigen-Specific Peripheral Tolerance Induction as a Therapy for Experimental Autoimmune Encephalomyelitis

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