Heart failure is a growing clinical problem, and inherited cardiomyopathies contribute significantly to heart failure. Among the many genes associated with inherited cardiomyopathies, mutations in FLNC, the gene encoding the cytoskeletal protein filamin C, associate with a range of cardiomyopathy and increased risk for arrhythmia and sudden cardiac death in...
Biologically active small molecules remain the foundation for the medical management of human disease. Their impacts on human health, longevity, culture, and society are difficultly overstated. In large part, medicines derived from organic compounds are the result of the tireless efforts of chemical practitioners––both past and present––who have dedicated much...