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Engineering Scalable Microenvironments to Enhance Ex Vivo Megakaryocyte Production and Platelet Release

Description:

Currently, platelet transfusions, possessing profound clinical importance in the clotting of blood and healing of wounds, are entirely derived from human volunteer donors. This approach is limited by a 5-day shelf life, the potential risk of contamination, and differences in donor/recipient immunology. In vivo, platelets are formed when bone marrow...

Keyword:

Applied sciences, Biological sciences, Megakaryocyte, Cell therapies, Computational fluid dynamics, and Microfluidic bioreactor

Subject:

Bioengineering, Chemical engineering, and Cellular biology

Creator:

Martinez, Andres Felipe

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_657405 and http://dissertations.umi.com/northwestern:14571
Studies of the Epigenetic Regulator NSD2 by Targeted and Quantitative Mass Spectrometry

Description:

Epigenetics is the study of chromatin-based events that regulate gene expression without the change of DNA sequence, including DNA methylation, histone modification and chromatin remodeling. Epigenetic regulators are encoded to modify chromatin in a highly regulated and dynamic manner. A growing number of studies have suggested the dysregulation of epigenetic...

Keyword:

Biological sciences, Histone methylation, Proteomics, Mass spectrometry, Protein interaction, and Epigenetics

Subject:

Analytical chemistry, Molecular biology, and Biochemistry

Creator:

Huang, Xiaoxiao

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_686355 and http://dissertations.umi.com/northwestern:14838

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Engineering Scalable Microenvironments to Enhance Ex Vivo Megakaryocyte Production and Platelet Release

Studies of the Epigenetic Regulator NSD2 by Targeted and Quantitative Mass Spectrometry

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