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Structural and Functional Analyses of Herpes Simplex Virus Type1 Glycoproteins B and L, Two Essential Components of the Viral Fusogenic Complex

Description:: Herpes simplex virus (HSV) infection of host cells requires virus attachment to the cell surface and subsequent membrane fusion between the virus envelope and host cell membrane to deliver the nucleocapsid containing the viral genome into the host cell. A proposed mechanism for HSV glycoprotein-induced membrane fusion is gD binding...
Keyword:: Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Erick Lin
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/17/2018
Date Modified:: 09/17/2018
Date Created:: 2008-07-17
Resource Type:: Dissertation

Mechanisms of Oxygen Sensing and Hypoxic Increase in Replicative Lifespan

Description:: The response to reduced levels of oxygen (hypoxia) is essential for embryonic development by promoting the proper formation of vascular networks. Conversely, hypoxia also promotes the development of pathophysiological processes such as pulmonary hypertension and cancer. The main mediator of responses to hypoxia within the cell is the transcription factor...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Eric Bell
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/01/2018
Date Modified:: 08/01/2018
Date Created:: 07-27-2007
Resource Type:: Dissertation

The Role of TGF-beta Variants in Breast Cancer

Description:: TGF-β has been named the molecular Jekyll and Hyde of cancer due to its ability to both suppress and promote tumor development. Components of the TGF-β signaling pathway are often mutated in cancer to inhibit the tumor suppressor roles of TGF-β. Our lab studies how a 3-alanine deletion in the...
Keyword:: Biology and Genetics
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Diana Susan Rosman
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/01/2018
Date Modified:: 10/01/2018
Date Created:: 2008-10-14
Resource Type:: Dissertation

Analysis of Latent Membrane Protein (LMP) 2A Signaling Through Src Family Kinases and the Role of LMP2B in Modulating LMP2A Signaling

Description:: Latent membrane protein 2A (LMP2A) and LMP2B are viral proteins expressed during Epstein-Barr virus (EBV) latency in EBV-infected B cells both in cell culture and in vivo. Although Lyn has been shown to be important in mediating LMP2A signaling, it is still unclear if Lyn is used preferentially or if...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Mark Rovedo
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/18/2018
Date Modified:: 09/18/2018
Date Created:: 2008-09-03
Resource Type:: Dissertation

Type II Secretion and Secreted Ppiases Promote Low Temperature Growth and Survival in Legionella pneumophila

Description:: PilD is an enzyme that processes prepilins that are part of the type II protein secretion apparatus and the type IV piliation machinery. Using a <em>Legionella pneumophila pilDlacZ</em> fusion strain to measure transcription, we observed a 20% increase in beta-galactosidase levels at 30°C vs. 37°C. At 25°C and 17°C vs....
Keyword:: Microbiology and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Maria Soderberg
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/06/2018
Date Modified:: 09/06/2018
Date Created:: 2008-03-25
Resource Type:: Dissertation

Analysis of the Requirement of Notch Signaling for EBV LMP2A Function in vitro and in vivo

Description:: Epstein Barr Virus (EBV) is associated with malignancies of lymphoid and epithelial origin. While the precise role of EBV in oncogenesis remains elusive, latent membrane protein 2A (LMP2A) is detected in all EBV-associated malignancies, implicating LMP2A in their pathogenesis. Interestingly, LMP2A is expressed in EBV-associated malignancies such as Burkitt's Lymphoma,...
Keyword:: Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Leah J Anderson
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/31/2018
Date Modified:: 08/31/2018
Date Created:: 2008-03-31
Resource Type:: Dissertation

Inhibition of Caspases by the Small Heat Shock Protein, HspB2

Description:: HspB2 was discovered as a chaperone of muscular dystrophy protein kinase (DMPK) and originally named, DMPK binding protein (MKBP) and presently called HspB2. Functionally, MKBP binds to DMPK and stabilizes its kinase activity, thereby accelerating the progression of muscular dystrophy. Although other binding partners of HspB2 have been found, the...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Shayna Oshita
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/27/2018
Date Modified:: 08/27/2018
Date Created:: 2007-08-28
Resource Type:: Dissertation

TGF-beta and caner development: the role of TGF-beta in converting CD4+CD25- T cells into CD4+CD25+ T regulatroy cells and a TbRIIDN-tk/Ganciclovir suicide system in cancer gene therapy

Description:: Initial studies described the ability of CD4+CD25+ T regulatory (Treg) cells in suppressing autoimmune diseases in animal models. An emerging interest has focused on the potential role of Treg cells in cancer development and progression as they have been shown to suppress anti-tumor immunity. In the present study, CD4+CD25- T...
Keyword:: Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Victoria Chunyan Liu
Owner:: Scholarly Digital Publishing
Date Uploaded:: 06/26/2018
Date Modified:: 06/26/2018
Date Created:: 2007-05-15
Resource Type:: Dissertation

Understanding the mechanism of protein processing by the proteasome

Description:: The ubiquitin-proteasome system degrades regulatory proteins and thereby controls a broad range of cellular processes such as the cell cycle, DNA-repair, gene transcription and signal transduction. The proteasome typically degrades its substrates completely into small peptides. However, biological exceptions do occur. For example, the activity of a handful of transcriptional...
Keyword:: Chemistry, Biology, and Cell
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Tian Lin
Owner:: Scholarly Digital Publishing
Date Uploaded:: 06/05/2018
Date Modified:: 06/05/2018
Date Created:: 2007-05-09
Resource Type:: Dissertation

Functional Characterization of Epstein-Barr Virus gH/gL Glycoprotein Complex in Fusion

Description:: Epstein-Barr virus (EBV) is a human gamma-herpesvirus that primarily infects B cells and epithelial cells. While the glycoproteins required for entry into these two cell types differ, the gH/gL glycoprotein complex is essential for entry into both epithelial and B cells. Analysis of gH protein sequences from three gamma-herpesviruses: EBV,...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Jasmina Omerovic
Owner:: Scholarly Digital Publishing
Date Uploaded:: 06/05/2018
Date Modified:: 06/05/2018
Date Created:: 2007-05-09
Resource Type:: Dissertation

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Structural and Functional Analyses of Herpes Simplex Virus Type1 Glycoproteins B and L, Two Essential Components of the Viral Fusogenic Complex

Mechanisms of Oxygen Sensing and Hypoxic Increase in Replicative Lifespan

The Role of TGF-beta Variants in Breast Cancer

Analysis of Latent Membrane Protein (LMP) 2A Signaling Through Src Family Kinases and the Role of LMP2B in Modulating LMP2A Signaling

Type II Secretion and Secreted Ppiases Promote Low Temperature Growth and Survival in Legionella pneumophila

Analysis of the Requirement of Notch Signaling for EBV LMP2A Function in vitro and in vivo

Inhibition of Caspases by the Small Heat Shock Protein, HspB2

TGF-beta and caner development: the role of TGF-beta in converting CD4+CD25- T cells into CD4+CD25+ T regulatroy cells and a TbRIIDN-tk/Ganciclovir suicide system in cancer gene therapy

Understanding the mechanism of protein processing by the proteasome

Functional Characterization of Epstein-Barr Virus gH/gL Glycoprotein Complex in Fusion

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