Northwestern University

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Growth inhibition of KRAS mutant cell lines via cleavage of RAS by RAS/RAP1 specific protease

Description:

RAS is one of the most frequently mutated oncogenes in cancer with ~30% of all human tumors harboring a mutation in either HRAS, NRAS, or KRAS isoforms. Despite countless efforts for the development of small molecule inhibitors for RAS, it remains an elusive target in the clinic. Here I demonstrate...

Keyword:

CDK, Cell cycle, RRSP, RAS, and p27

Subject:

Oncology

Creator:

Stubbs, Caleb Kawun

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15927 and etdadmin_upload_879045