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Structural Visualization of State Transition during Non-Homologous End-Joining (NHEJ)

Description:

DNA double-strand breaks (DSBs) are caused by either endogenous agents or exogenous ionizing radiation and chemicals. Incorrect DSB repair can lead to undesired genome rearrangements. Homologous recombination (HR) and non-homologous end-joining (NHEJ) pathways are two major DNA repair pathways that repair DSBs and maintain genome integrity. When homologous DNA is...

Keyword:

DNA repair, Cryo EM, NHEJ, DNA-PKcs, Cancer, and CRISPR

Subject:

Molecular biology, Biochemistry, and Biophysics

Creator:

Chen, Siyu

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_879511 and http://dissertations.umi.com/northwestern:15936
Defining and Therapeutically Targeting IDH1-WT Oncogenicity in GBM

Description:

Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system tumor, characterized by resistance to therapeutic intervention, inevitable recurrence, and ultimately patient death. The dismal prognosis is due in part to underlying molecular factors that promote an intratumoral cellular state heterogeneity and protect tumor cells from cell death pathways....

Keyword:

Ferroptosis, Glioblastoma, Cancer, Stemness, Metabolism, and IDH1

Subject:

Molecular biology, Medicine, and Neurosciences

Creator:

Murnan, Kevin Michael

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15885 and etdadmin_upload_865864

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Structural Visualization of State Transition during Non-Homologous End-Joining (NHEJ)

Defining and Therapeutically Targeting IDH1-WT Oncogenicity in GBM

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